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- W2007720452 abstract "Abstract Background Microglia/macrophages and lymphocytes (T-cells) accumulate around motor and primary sensory neurons that are regenerating axons but there is little or no microglial activation or T-cell accumulation around axotomised intrinsic CNS neurons, which do not normally regenerate axons. We aimed to establish whether there was an inflammatory response around the perikarya of CNS neurons that were induced to regenerate axons through a peripheral nerve graft. Results When neurons of the thalamic reticular nucleus (TRN) and red nucleus were induced to regenerate axons along peripheral nerve grafts, a marked microglial response was found around their cell bodies, including the partial enwrapping of some regenerating neurons. T-cells were found amongst regenerating TRN neurons but not rubrospinal neurons. Axotomy alone or insertion of freeze-killed nerve grafts did not induce a similar perineuronal inflammation. Nerve grafts in the corticospinal tracts did not induce axonal regeneration or a microglial or T-cell response in the motor cortex. Conclusions These results strengthen the evidence that perineuronal microglial accumulation (but not T-cell accumulation) is involved in axonal regeneration by intrinsic CNS and other neurons." @default.
- W2007720452 created "2016-06-24" @default.
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- W2007720452 date "2010-02-05" @default.
- W2007720452 modified "2023-10-15" @default.
- W2007720452 title "Microglial responses around intrinsic CNS neurons are correlated with axonal regeneration" @default.
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- W2007720452 doi "https://doi.org/10.1186/1471-2202-11-13" @default.
- W2007720452 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2829570" @default.
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