Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007736276> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2007736276 endingPage "97" @default.
- W2007736276 startingPage "93" @default.
- W2007736276 abstract "The mitogenic effect of spheroids of the human colorectal cancer cell line HT29 on a monolayer of bovine capilarly endothelial cells was investigated to determine the relationship between aspects of three-dimensional tumor growth and endothelial cell mitogenesis. Spheroid-conditioned media caused a significant increase in the labeling index (LI) of endothelial cells over control values. An inverse relationship was found between the age of spheroids and their ability to produce endothelial mitogens. Young (day 5) spheroids induced a significantly higher LI in endothelial cells than more mature ones. The decrease in mitogenicity preceded the development of necrosis in the spheroids. Futhermore, conditioned medium from mature (day 21) spheroids suppressed the mitogenic activity from young spheroids to a significant degree, indicating that larger tumor nodules may produce inhibitors of endothelial cell proliferation. The model described here indicates that further studies with young and mature spheroids could provide important information on the regulating mechanisms exerted by growing tumor nodules on tumor-associated angiogenesis." @default.
- W2007736276 created "2016-06-24" @default.
- W2007736276 creator A5031899924 @default.
- W2007736276 creator A5052548319 @default.
- W2007736276 date "1993-01-01" @default.
- W2007736276 modified "2023-09-27" @default.
- W2007736276 title "Mitogenic Properties of Tumor Spheroids for Endothelial Cells Are Related to Their Age" @default.
- W2007736276 cites W1862348948 @default.
- W2007736276 cites W1973893754 @default.
- W2007736276 cites W1975173778 @default.
- W2007736276 cites W1984927564 @default.
- W2007736276 cites W2004184531 @default.
- W2007736276 cites W2010618512 @default.
- W2007736276 cites W2013456954 @default.
- W2007736276 cites W2014637739 @default.
- W2007736276 cites W2037309650 @default.
- W2007736276 cites W2041585886 @default.
- W2007736276 cites W2048381117 @default.
- W2007736276 cites W2065320333 @default.
- W2007736276 cites W2092671785 @default.
- W2007736276 cites W2094958641 @default.
- W2007736276 cites W2106448082 @default.
- W2007736276 cites W2134582008 @default.
- W2007736276 cites W2154668531 @default.
- W2007736276 cites W2158743409 @default.
- W2007736276 cites W2319962899 @default.
- W2007736276 cites W37292645 @default.
- W2007736276 cites W4255042798 @default.
- W2007736276 cites W63256203 @default.
- W2007736276 doi "https://doi.org/10.3109/10623329309102315" @default.
- W2007736276 hasPublicationYear "1993" @default.
- W2007736276 type Work @default.
- W2007736276 sameAs 2007736276 @default.
- W2007736276 citedByCount "0" @default.
- W2007736276 crossrefType "journal-article" @default.
- W2007736276 hasAuthorship W2007736276A5031899924 @default.
- W2007736276 hasAuthorship W2007736276A5052548319 @default.
- W2007736276 hasConcept C123012128 @default.
- W2007736276 hasConcept C1491633281 @default.
- W2007736276 hasConcept C175369904 @default.
- W2007736276 hasConcept C185592680 @default.
- W2007736276 hasConcept C202751555 @default.
- W2007736276 hasConcept C203014093 @default.
- W2007736276 hasConcept C2780394083 @default.
- W2007736276 hasConcept C502942594 @default.
- W2007736276 hasConcept C54355233 @default.
- W2007736276 hasConcept C55493867 @default.
- W2007736276 hasConcept C62112901 @default.
- W2007736276 hasConcept C81885089 @default.
- W2007736276 hasConcept C86803240 @default.
- W2007736276 hasConcept C95444343 @default.
- W2007736276 hasConceptScore W2007736276C123012128 @default.
- W2007736276 hasConceptScore W2007736276C1491633281 @default.
- W2007736276 hasConceptScore W2007736276C175369904 @default.
- W2007736276 hasConceptScore W2007736276C185592680 @default.
- W2007736276 hasConceptScore W2007736276C202751555 @default.
- W2007736276 hasConceptScore W2007736276C203014093 @default.
- W2007736276 hasConceptScore W2007736276C2780394083 @default.
- W2007736276 hasConceptScore W2007736276C502942594 @default.
- W2007736276 hasConceptScore W2007736276C54355233 @default.
- W2007736276 hasConceptScore W2007736276C55493867 @default.
- W2007736276 hasConceptScore W2007736276C62112901 @default.
- W2007736276 hasConceptScore W2007736276C81885089 @default.
- W2007736276 hasConceptScore W2007736276C86803240 @default.
- W2007736276 hasConceptScore W2007736276C95444343 @default.
- W2007736276 hasIssue "2" @default.
- W2007736276 hasLocation W20077362761 @default.
- W2007736276 hasOpenAccess W2007736276 @default.
- W2007736276 hasPrimaryLocation W20077362761 @default.
- W2007736276 hasRelatedWork W2009173078 @default.
- W2007736276 hasRelatedWork W2012753522 @default.
- W2007736276 hasRelatedWork W2052926478 @default.
- W2007736276 hasRelatedWork W2054183105 @default.
- W2007736276 hasRelatedWork W2083693850 @default.
- W2007736276 hasRelatedWork W2091139028 @default.
- W2007736276 hasRelatedWork W2889735140 @default.
- W2007736276 hasRelatedWork W2993990633 @default.
- W2007736276 hasRelatedWork W3106917159 @default.
- W2007736276 hasRelatedWork W3178515596 @default.
- W2007736276 hasVolume "1" @default.
- W2007736276 isParatext "false" @default.
- W2007736276 isRetracted "false" @default.
- W2007736276 magId "2007736276" @default.
- W2007736276 workType "article" @default.