FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007741160> ?p ?o ?g. }

• W2007741160 endingPage "1107" @default.
• W2007741160 startingPage "1101" @default.
• W2007741160 abstract "The insulin-like growth factor-I receptor (IGF-IR) is involved in tumorigenesis. The aim of the present study was to investigate whether the IGF-IR is a physiological target for p53 in osteosarcoma cells. The p53-induced regulation of IGF-IR levels was studied in a tetracycline-regulated expression system. When expressed in Saos-2, osteosarcoma cells that lack p53, wild-type p53 decreased, whereas mutated p53 increased IGF-IR expression, and IGF-I-induced tyrosine phosphorylation of the IGF-IR. Similarly, wild-type p53 decreased IGF-I-induced tyrosine phosphorylation of IRS-1. A functional and physical interaction between p53 and Sp1, in the regulation of the IGF-R, was studied in osteosarcoma cells. Expression of p53 decreased IGF-IR promoter activity, whereas no effect on promoter activity was seen by Sp1 expressed alone. However, Sp1 counteracted the inhibitory effect of p53 on IGF-IR promoter activity in a dose-dependent manner. Furthermore, wild-type and mutated p53 were coimmunoprecipitated with Sp1, indicating a physical interaction between p53 and Sp1. In conclusion, p53 regulates IGF-IR expression, as reflected by a reduction in IGF-IR protein and a parallel reduction in IGF-I-induced tyrosine phosphorylation of the IGF-IR and IRS-1 in an osteosarcoma cell line. These data indicate that the IGF-I receptor is a physiological target for p53 in osteosarcoma cells. Furthermore, data supporting an interaction between p53 and Sp1 in the regulation of the promoter activity of IGF-IR are presented." @default.
• W2007741160 created "2016-06-24" @default.
• W2007741160 creator A5003904670 @default.
• W2007741160 creator A5047769764 @default.
• W2007741160 creator A5070276458 @default.
• W2007741160 creator A5091032474 @default.
• W2007741160 date "1998-03-01" @default.
• W2007741160 modified "2023-10-18" @default.
• W2007741160 title "p53 Regulates Insulin-Like Growth Factor-I (IGF-I) Receptor Expression and IGF-I-Induced Tyrosine Phosphorylation in an Osteosarcoma Cell Line: Interaction between p53 and Sp1" @default.
• W2007741160 cites W1493260667 @default.
• W2007741160 cites W1547769073 @default.
• W2007741160 cites W1570592780 @default.
• W2007741160 cites W1584184269 @default.
• W2007741160 cites W1595424043 @default.
• W2007741160 cites W182803491 @default.
• W2007741160 cites W1944714834 @default.
• W2007741160 cites W1952468142 @default.
• W2007741160 cites W1964224010 @default.
• W2007741160 cites W1969881374 @default.
• W2007741160 cites W1970285990 @default.
• W2007741160 cites W1973418379 @default.
• W2007741160 cites W1976468253 @default.
• W2007741160 cites W1983649348 @default.
• W2007741160 cites W1994555790 @default.
• W2007741160 cites W2002558069 @default.
• W2007741160 cites W2005250554 @default.
• W2007741160 cites W2012940389 @default.
• W2007741160 cites W2029559050 @default.
• W2007741160 cites W2042316019 @default.
• W2007741160 cites W2042854276 @default.
• W2007741160 cites W2045893297 @default.
• W2007741160 cites W2047537929 @default.
• W2007741160 cites W2061154169 @default.
• W2007741160 cites W2068691401 @default.
• W2007741160 cites W2069408483 @default.
• W2007741160 cites W2070203770 @default.
• W2007741160 cites W2077321849 @default.
• W2007741160 cites W2077919252 @default.
• W2007741160 cites W2079327471 @default.
• W2007741160 cites W2085020132 @default.
• W2007741160 cites W2090025028 @default.
• W2007741160 cites W2094646101 @default.
• W2007741160 cites W2102437478 @default.
• W2007741160 cites W2103340147 @default.
• W2007741160 cites W2117584675 @default.
• W2007741160 cites W2118980160 @default.
• W2007741160 cites W2127526484 @default.
• W2007741160 cites W2127952872 @default.
• W2007741160 cites W2130258789 @default.
• W2007741160 cites W2148932752 @default.
• W2007741160 cites W2255703111 @default.
• W2007741160 cites W2341209396 @default.
• W2007741160 cites W53883515 @default.
• W2007741160 doi "https://doi.org/10.1210/endo.139.3.5832" @default.
• W2007741160 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9492043" @default.
• W2007741160 hasPublicationYear "1998" @default.
• W2007741160 type Work @default.
• W2007741160 sameAs 2007741160 @default.
• W2007741160 citedByCount "132" @default.
• W2007741160 countsByYear W20077411602012 @default.
• W2007741160 countsByYear W20077411602013 @default.
• W2007741160 countsByYear W20077411602014 @default.
• W2007741160 countsByYear W20077411602015 @default.
• W2007741160 countsByYear W20077411602016 @default.
• W2007741160 countsByYear W20077411602017 @default.
• W2007741160 countsByYear W20077411602018 @default.
• W2007741160 countsByYear W20077411602019 @default.
• W2007741160 countsByYear W20077411602020 @default.
• W2007741160 countsByYear W20077411602021 @default.
• W2007741160 countsByYear W20077411602022 @default.
• W2007741160 countsByYear W20077411602023 @default.
• W2007741160 crossrefType "journal-article" @default.
• W2007741160 hasAuthorship W2007741160A5003904670 @default.
• W2007741160 hasAuthorship W2007741160A5047769764 @default.
• W2007741160 hasAuthorship W2007741160A5070276458 @default.
• W2007741160 hasAuthorship W2007741160A5091032474 @default.
• W2007741160 hasBestOaLocation W20077411601 @default.
• W2007741160 hasConcept C104317684 @default.
• W2007741160 hasConcept C11960822 @default.
• W2007741160 hasConcept C126322002 @default.
• W2007741160 hasConcept C134018914 @default.
• W2007741160 hasConcept C153911025 @default.
• W2007741160 hasConcept C170493617 @default.
• W2007741160 hasConcept C2775960820 @default.
• W2007741160 hasConcept C2776165026 @default.
• W2007741160 hasConcept C2777553839 @default.
• W2007741160 hasConcept C2777760704 @default.
• W2007741160 hasConcept C2780689927 @default.
• W2007741160 hasConcept C502942594 @default.
• W2007741160 hasConcept C54355233 @default.
• W2007741160 hasConcept C55493867 @default.
• W2007741160 hasConcept C555283112 @default.
• W2007741160 hasConcept C71924100 @default.
• W2007741160 hasConcept C81885089 @default.
• W2007741160 hasConcept C86803240 @default.
• W2007741160 hasConcept C95444343 @default.
• W2007741160 hasConceptScore W2007741160C104317684 @default.
• W2007741160 hasConceptScore W2007741160C11960822 @default.

• next