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• W2007744384 startingPage "e41307" @default.
• W2007744384 abstract "Chlamydomonas reinhardtii is a model system for studying cilia, photosynthesis, and other core features of eukaryotes, and is also an emerging source of biofuels. Despite its importance to basic and applied biological research, the level and pattern of genetic variation in this haploid green alga has yet to be characterized on a genome-wide scale. To improve understanding of C. reinhardtii's genetic variability, we generated low coverage whole genome resequencing data for nearly all of the available isolates of this species, which were sampled from a number of sites in North America over the past ∼70 years. Based on the analysis of more than 62,000 single nucleotide polymorphisms, we identified two groups of isolates that represent geographical subpopulations of the species. We also found that measurements of genetic diversity were highly variable throughout the genome, in part due to technical factors. We studied the level and pattern of linkage disequilibrium (LD), and observed one chromosome that exhibits elevated LD. Furthermore, we detected widespread evidence of recombination across the genome, which implies that outcrossing occurs in natural populations of this species. In summary, our study provides multiple insights into the sequence diversity of C. reinhardtii that will be useful to future studies of natural genetic variation in this organism." @default.
• W2007744384 created "2016-06-24" @default.
• W2007744384 creator A5018798845 @default.
• W2007744384 creator A5070784329 @default.
• W2007744384 date "2012-07-25" @default.
• W2007744384 modified "2023-09-25" @default.
• W2007744384 title "Genome-Wide Characterization of Genetic Variation in the Unicellular, Green Alga Chlamydomonas reinhardtii" @default.
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• W2007744384 doi "https://doi.org/10.1371/journal.pone.0041307" @default.
• W2007744384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3405113" @default.
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