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- W2007746539 abstract "Abstract LA 334 (previously ts 75) has been identified as a mutant exhibiting two genetic lesions affecting late functions of the avian sarcoma virus genome. One causes the transformed phenotype to be temperature sensitive, and the other induces a rapidly reversible inhibition of progeny virus production at the nonpermissive temperature. The nature of the latter defect has been investigated in this study with the following findings: (1) no new protein synthesis was needed to initiate synthesis of infectious virus after a shift from the nonpermissive to the permissive temperature; (2) significant amounts of physical particles (20 to 70% of that produced at the permissive temperature) were produced at the nonpermissive temperature; and (3) intracellular accumulation of structures resembling budding virus, approximately 80% of which were aberrant, were observed in mutant-infected cells at the nonpermissive temperature. The possibility that a defect in the synthesis of the viral envelope glycoprotein, gp85, would account for these findings prompted an investigation of the expression of gp85 in LA 334-infected cells. Intracellular synthesis of gp85 in normal amounts was shown by immunoprecipitation; however, only inefficient interference against superinfecting virus could be observed with mutant-infected cells at the nonpermissive temperature. Immunoferritin electron microscopic observations also indicated the presence of envelope glycoprotein in association with budding virions of normal morphology, but in contrast, little or no glycoprotein was associated with the budding structures of aberrant morphology. It is concluded that the primary virus defect is not related to expression of gp85; rather, on the basis of the abnormal core assembly, it is proposed that a defect exists in one of the core structural proteins. This hypothesis is discussed in the light of known properties of the mutant and of certain recent observations on the composition of the noninfectious virus produced by infected cells at the nonpermissive temperature." @default.
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- W2007746539 date "1976-08-01" @default.
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- W2007746539 title "The defective maturation of viral progeny with a temperature-sensitive mutant of avian sarcoma virus" @default.
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- W2007746539 doi "https://doi.org/10.1016/0042-6822(76)90079-9" @default.
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