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• W2007749871 abstract "<b><i>Background:</i></b> To assess the prevalence of thrombophilia in patients with central (CRVO) and branch retinal vein occlusion (BRVO). <b><i>Methods:</i></b> In 139 patients with CRVO (n = 88) and BRVO (n = 51) and in 40 healthy controls factor VIII, fibrinogen, antithrombin III, protein C, protein S, activated protein C resistance, anticardiolipin antibodies (ACA), homocysteine, factor V Leiden, prothrombin G20210A and methylene tetrahydrofolate reductase (MTHFR) C677T mutation were assessed retrospectively. <b><i>Results:</i></b> Elevated factor VIII activity and the homozygous MTHFR C677T mutation were significantly more often found in CRVO and BRVO cases compared to controls. Age-, gender- and C-reactive protein-adjusted logistic regression analysis did not show a significant additive effect of elevated factor VIII activity on the risk of developing CRVO/BRVO. Elevated fibrinogen levels and ACA were significantly more often found in CRVO than amongst controls. No significant differences were found concerning the remaining variables. <b><i>Conclusions:</i></b> We suggest elevated fibrinogen levels, ACA and the homozygous MTHFR C677T mutation as potential risk factors for CRVO/BRVO." @default.
• W2007749871 created "2016-06-24" @default.
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• W2007749871 date "2014-01-01" @default.
• W2007749871 modified "2023-10-18" @default.
• W2007749871 title "Thrombophilia in Patients with Retinal Vein Occlusion: A Retrospective Analysis" @default.
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• W2007749871 doi "https://doi.org/10.1159/000360013" @default.
• W2007749871 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24853960" @default.
• W2007749871 hasPublicationYear "2014" @default.
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