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• W2007751477 endingPage "e1004400" @default.
• W2007751477 startingPage "e1004400" @default.
• W2007751477 abstract "Altered cell metabolism is inherently connected with pathological conditions including cancer and viral infections. Kaposi's sarcoma-associated herpesvirus (KSHV) is the etiological agent of Kaposi's sarcoma (KS). KS tumour cells display features of lymphatic endothelial differentiation and in their vast majority are latently infected with KSHV, while a small number are lytically infected, producing virions. Latently infected cells express only a subset of viral genes, mainly located within the latency-associated region, among them 12 microRNAs. Notably, the metabolic properties of KSHV-infected cells closely resemble the metabolic hallmarks of cancer cells. However, how and why KSHV alters host cell metabolism remains poorly understood. Here, we investigated the effect of KSHV infection on the metabolic profile of primary dermal microvascular lymphatic endothelial cells (LEC) and the functional relevance of this effect. We found that the KSHV microRNAs within the oncogenic cluster collaborate to decrease mitochondria biogenesis and to induce aerobic glycolysis in infected cells. KSHV microRNAs expression decreases oxygen consumption, increase lactate secretion and glucose uptake, stabilize HIF1α and decreases mitochondria copy number. Importantly this metabolic shift is important for latency maintenance and provides a growth advantage. Mechanistically we show that KSHV alters host cell energy metabolism through microRNA-mediated down regulation of EGLN2 and HSPA9. Our data suggest that the KSHV microRNAs induce a metabolic transformation by concurrent regulation of two independent pathways; transcriptional reprograming via HIF1 activation and reduction of mitochondria biogenesis through down regulation of the mitochondrial import machinery. These findings implicate viral microRNAs in the regulation of the cellular metabolism and highlight new potential avenues to inhibit viral latency." @default.
• W2007751477 created "2016-06-24" @default.
• W2007751477 creator A5029148332 @default.
• W2007751477 creator A5046807661 @default.
• W2007751477 creator A5059661708 @default.
• W2007751477 creator A5070268238 @default.
• W2007751477 date "2014-09-25" @default.
• W2007751477 modified "2023-10-10" @default.
• W2007751477 title "Kaposi's Sarcoma Herpesvirus MicroRNAs Induce Metabolic Transformation of Infected Cells" @default.
• W2007751477 cites W1481548475 @default.
• W2007751477 cites W1501718277 @default.
• W2007751477 cites W1874303456 @default.
• W2007751477 cites W1965549777 @default.
• W2007751477 cites W1965634572 @default.
• W2007751477 cites W1967874387 @default.
• W2007751477 cites W1968651533 @default.
• W2007751477 cites W1977500292 @default.
• W2007751477 cites W1978020339 @default.
• W2007751477 cites W1979246886 @default.
• W2007751477 cites W1981182976 @default.
• W2007751477 cites W1982209692 @default.
• W2007751477 cites W1982537801 @default.
• W2007751477 cites W1983447693 @default.
• W2007751477 cites W1987328298 @default.
• W2007751477 cites W1988377666 @default.
• W2007751477 cites W1991421091 @default.
• W2007751477 cites W1992808621 @default.
• W2007751477 cites W1994900589 @default.
• W2007751477 cites W2000744297 @default.
• W2007751477 cites W2002364392 @default.
• W2007751477 cites W2005828644 @default.
• W2007751477 cites W2005868568 @default.
• W2007751477 cites W2010009570 @default.
• W2007751477 cites W2011810742 @default.
• W2007751477 cites W2012861249 @default.
• W2007751477 cites W2016160962 @default.
• W2007751477 cites W2016496152 @default.
• W2007751477 cites W2027881705 @default.
• W2007751477 cites W2028378804 @default.
• W2007751477 cites W2032438721 @default.
• W2007751477 cites W2033064329 @default.
• W2007751477 cites W2033350358 @default.
• W2007751477 cites W2034773856 @default.
• W2007751477 cites W2035310028 @default.
• W2007751477 cites W2035983112 @default.
• W2007751477 cites W2040191060 @default.
• W2007751477 cites W2041055602 @default.
• W2007751477 cites W2042400567 @default.
• W2007751477 cites W2046984465 @default.
• W2007751477 cites W2050140657 @default.
• W2007751477 cites W2055202552 @default.
• W2007751477 cites W2064640692 @default.
• W2007751477 cites W2067444184 @default.
• W2007751477 cites W2072047081 @default.
• W2007751477 cites W2075394689 @default.
• W2007751477 cites W2083381199 @default.
• W2007751477 cites W2083829813 @default.
• W2007751477 cites W2084034472 @default.
• W2007751477 cites W2086965865 @default.
• W2007751477 cites W2087025873 @default.
• W2007751477 cites W2091288867 @default.
• W2007751477 cites W2097200312 @default.
• W2007751477 cites W2098754973 @default.
• W2007751477 cites W2098902167 @default.
• W2007751477 cites W2098972920 @default.
• W2007751477 cites W2102416115 @default.
• W2007751477 cites W2107268184 @default.
• W2007751477 cites W2112077864 @default.
• W2007751477 cites W2118603752 @default.
• W2007751477 cites W2120246830 @default.
• W2007751477 cites W2121918395 @default.
• W2007751477 cites W2122028337 @default.
• W2007751477 cites W2126711569 @default.
• W2007751477 cites W2128557475 @default.
• W2007751477 cites W2131211568 @default.
• W2007751477 cites W2132927652 @default.
• W2007751477 cites W2133897047 @default.
• W2007751477 cites W2140751228 @default.
• W2007751477 cites W2141935262 @default.
• W2007751477 cites W2144954025 @default.
• W2007751477 cites W2149785901 @default.
• W2007751477 cites W2152736091 @default.
• W2007751477 cites W2158902191 @default.
• W2007751477 cites W2161071327 @default.
• W2007751477 cites W2161336519 @default.
• W2007751477 cites W2162674813 @default.
• W2007751477 cites W2163199119 @default.
• W2007751477 cites W2170725518 @default.
• W2007751477 cites W2220171020 @default.
• W2007751477 cites W2336241188 @default.
• W2007751477 cites W2410723119 @default.
• W2007751477 cites W4246620890 @default.
• W2007751477 doi "https://doi.org/10.1371/journal.ppat.1004400" @default.
• W2007751477 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4177984" @default.
• W2007751477 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25255370" @default.
• W2007751477 hasPublicationYear "2014" @default.
• W2007751477 type Work @default.
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