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- W2007753491 abstract "The role of neutrophils in the conversion of big endothelin (Big-ET) to endothelin-1 (ET-1) was assessed in two models. In rabbit isolated hearts, ET-1 demonstrated significant increases in coronary perfusion pressure (PP) at doses greater than 100 pmol. With Big-ET, significant increases were obtained only at doses greater than 3 nmol. Similarly, this dose of Big-ET did not increase PP in isolated, perfused hearts from rabbits previously subjected to 60 min of coronary artery occlusion and 4 h of reperfusion (n = 7). However, when isolated rabbit neutrophils were incubated with Big-ET (n = 5) or vehicle (n = 4) and 3 nmol aliquots assayed in isolated hearts, results demonstrated a time-dependent conversion to a vasoactive product. These findings suggest that isolated neutrophils are capable of converting Big-ET to an ET-1-like vasoactive substance. The model may be useful in assessing antagonists of endothelin-converting enzyme activity and/or the endothelin receptor." @default.
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- W2007753491 date "1993-01-01" @default.
- W2007753491 modified "2023-10-14" @default.
- W2007753491 title "Functional Consequence of Big Endothelin Conversion: Demonstration with Isolated Neutrophils But Not in a Postinfarction Model" @default.
- W2007753491 doi "https://doi.org/10.1159/000139108" @default.
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