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- W2007757183 abstract ": The plasma protein binding of diphenylhydantoin (DPH) in heparinized plasma from adult volunteers, DPH-treated adult patients with epilepsy, normal and hyperbilirubinaemic newborn infants was investigated, using an ultrafiltration technique (14C-labelled DPH). At room temperature (16 μg DPH/ml plasma) the bound fraction of DPH in 15 adult volunteers and 13 normal infants (cord blood) was 92.6 ± 0.7 and 89.4 ± 1.4 %, respectively. At 37° the unbound fraction of DPH was increased by some 60 %. Similar data were obtained in adult patients. Among a series of 15, mostly acidic drugs added in vitro in concentrations which may be obtained during therapy, only salicylic acid, sulfafurazole and phenylbutazone caused marked decrease in DPH-binding. Dilution experiments showed different patterns with regard to the bound and the unbound amounts (μg/ml) of DPH, depending on whether plasma was diluted only (constant DPH-concentration) or both DPH and plasma were diluted to the same extent. In a group of 20 hyperbilirubinaemic newborn infants a correlation existed between the unbound fraction of DPH and the total concentration of plasma bilirubin. A competition between DPH and bilirubin for similar binding sites on the albumin molecule is suggested." @default.
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- W2007757183 date "2009-03-13" @default.
- W2007757183 modified "2023-10-03" @default.
- W2007757183 title "Plasma Protein Binding of Diphenylhydantoin in Man" @default.
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- W2007757183 doi "https://doi.org/10.1111/j.1600-0773.1971.tb03294.x" @default.
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