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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007758921> ?p ?o ?g. }

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• W2007758921 abstract "Here, we tested seven 2-acylated-1,4-hydronaphthoquinones for their cytotoxic effects on a panel of cancer lymphoma/leukemia cells and compared to a non-cancer origin cell line. Several naphthohydroquinones exhibited selective cytotoxic effects on lymphoma/leukemia cells with lowest activity on non-cancer cells. The mode of cell death induced by an acylated naphthohydroquinone, which has a long alkyl chain, was found to be via apoptosis. Furthermore, the naphthohydroquinone provoked mitochondria depolarization and activation of its downstream effector, caspase-3, thus implicating the intrinsic apoptotic pathway as its mechanism to exert cell death." @default.
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• W2007758921 date "2014-01-01" @default.
• W2007758921 modified "2023-09-27" @default.
• W2007758921 title "The cytotoxic effect of 2-acylated-1,4-naphthohydroquinones on leukemia/lymphoma cells" @default.
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• W2007758921 doi "https://doi.org/10.1016/j.bmc.2013.12.007" @default.
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