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- W2007767137 abstract "The enzymatic peptide synthesis of two sweet aspartyl dipeptide analogs of the precursor to aspartame (Z-l-Asp-Phe-OMe), Z-l-Asp-Tyr-OMe and Z-l-Asp-Met-OMe was attempted using thermolysin as a catalyst. Synthesis of Z-l-Asp-Tyr-OMe and Z-l-Asp-Met-OMe was achieved although yields were much lower than the model dipeptide, Z-l-Asp-Phe-OMc. The experimental design with various conditions (solvent, pH, temperature; reactant, CaCl2 and enzyme concentration) was obtained by applying a computer optimizing technique, Random Centroid Optimization, to reduce the number of experiments required. Synthesis of the Met-containing dipeptide was more favorable than tyrosine, indicating thermolysin's specificity requirements for hydrolysis." @default.
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- W2007767137 date "1994-01-01" @default.
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- W2007767137 title "Enzymatic synthesis of two sweet aspartyl dipeptide analogs catalyzed by thermolysin" @default.
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- W2007767137 doi "https://doi.org/10.1016/0963-9969(94)90243-7" @default.
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