FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007767657> ?p ?o ?g. }

• W2007767657 endingPage "16" @default.
• W2007767657 startingPage "11" @default.
• W2007767657 abstract "Activin A, a member of the transforming growth factor β supergene family, modulates DNA synthesis in cultured rat vascular smooth muscle cells (VSMC) (Kopma et al. (1993) Exp. Cell. Res. 206, 152–156). In the present study, we studied the production of activin A and follistatin in VSMC. When VSMCs cultured in a 24-well plate were cultured with 10% fetal calf serum (FCS) for 24 h, 0.94 ± 0.20 pmol/well (mean ± SE, n = 6) of bioactive activin was released into the culture media. Reverse-transcription polymerase chain-reaction revealed the expression of mRNA for the βA subunit of inhibin but not for either the βB or α subunit. Bioactivity of activin was increased in quiescent cells treated with FCS or platelet-derived growth factor (PDGF) but not with angiotensin II (Ang II) or insulin-like growth factor-I (IGF-I). Ang II or IGF-I did not stimulate DNA synthesis by itself but, when these two agents were combined, they increased nuclear labeling by 16.4% and release of bioactive activin by 170% of basal. The dose-response relationship and time course study indicated that PDGF-mediated release of activin correlated with initiation of DNA synthesis. Steady state expression of mRNA for the βA subunit was markedly elevated 12 h after the addition of PDGF and was reduced thereafter. To assess the significance of autocrine activin, the effect of PDGF was determined in the presence and absence of excess of exogenous follistatin. The PDGF-mediated DNA synthesis was enhanced by the addition of excess follistatin. In addition to the production of activin, PDGF also enhanced release of follistatin from VSMC. These results indicate that VSMC synthesize and release both activin and follistatin and that the activin-follistatin system may modulate DNA synthesis in VSMC." @default.
• W2007767657 created "2016-06-24" @default.
• W2007767657 creator A5035883806 @default.
• W2007767657 creator A5038790620 @default.
• W2007767657 creator A5059120239 @default.
• W2007767657 creator A5065213823 @default.
• W2007767657 creator A5073161317 @default.
• W2007767657 creator A5083359523 @default.
• W2007767657 date "1995-02-01" @default.
• W2007767657 modified "2023-09-27" @default.
• W2007767657 title "Production of activin A and follistatin in cultured rat vascular smooth muscle cells" @default.
• W2007767657 cites W1502751847 @default.
• W2007767657 cites W1570507925 @default.
• W2007767657 cites W1588631671 @default.
• W2007767657 cites W1977509897 @default.
• W2007767657 cites W1982950882 @default.
• W2007767657 cites W1984114894 @default.
• W2007767657 cites W1986951033 @default.
• W2007767657 cites W1999704781 @default.
• W2007767657 cites W2017177010 @default.
• W2007767657 cites W2017990475 @default.
• W2007767657 cites W2023846059 @default.
• W2007767657 cites W2033158024 @default.
• W2007767657 cites W2045858906 @default.
• W2007767657 cites W2048345404 @default.
• W2007767657 cites W2055830220 @default.
• W2007767657 cites W2060889469 @default.
• W2007767657 cites W2065982341 @default.
• W2007767657 cites W2085131417 @default.
• W2007767657 cites W2091362072 @default.
• W2007767657 cites W2093628210 @default.
• W2007767657 cites W2093773022 @default.
• W2007767657 cites W2094422118 @default.
• W2007767657 cites W2097154687 @default.
• W2007767657 cites W2120927716 @default.
• W2007767657 cites W2134812217 @default.
• W2007767657 cites W2147834547 @default.
• W2007767657 cites W2171190610 @default.
• W2007767657 cites W4237493315 @default.
• W2007767657 cites W4243638929 @default.
• W2007767657 doi "https://doi.org/10.1016/0303-7207(94)03451-x" @default.
• W2007767657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7758823" @default.
• W2007767657 hasPublicationYear "1995" @default.
• W2007767657 type Work @default.
• W2007767657 sameAs 2007767657 @default.
• W2007767657 citedByCount "14" @default.
• W2007767657 countsByYear W20077676572017 @default.
• W2007767657 crossrefType "journal-article" @default.
• W2007767657 hasAuthorship W2007767657A5035883806 @default.
• W2007767657 hasAuthorship W2007767657A5038790620 @default.
• W2007767657 hasAuthorship W2007767657A5059120239 @default.
• W2007767657 hasAuthorship W2007767657A5065213823 @default.
• W2007767657 hasAuthorship W2007767657A5073161317 @default.
• W2007767657 hasAuthorship W2007767657A5083359523 @default.
• W2007767657 hasConcept C118131993 @default.
• W2007767657 hasConcept C126322002 @default.
• W2007767657 hasConcept C128240485 @default.
• W2007767657 hasConcept C134018914 @default.
• W2007767657 hasConcept C170493617 @default.
• W2007767657 hasConcept C180361614 @default.
• W2007767657 hasConcept C185592680 @default.
• W2007767657 hasConcept C2775960820 @default.
• W2007767657 hasConcept C2778831791 @default.
• W2007767657 hasConcept C2779395532 @default.
• W2007767657 hasConcept C2781294074 @default.
• W2007767657 hasConcept C2992686903 @default.
• W2007767657 hasConcept C552990157 @default.
• W2007767657 hasConcept C55493867 @default.
• W2007767657 hasConcept C64241487 @default.
• W2007767657 hasConcept C71924100 @default.
• W2007767657 hasConcept C86803240 @default.
• W2007767657 hasConceptScore W2007767657C118131993 @default.
• W2007767657 hasConceptScore W2007767657C126322002 @default.
• W2007767657 hasConceptScore W2007767657C128240485 @default.
• W2007767657 hasConceptScore W2007767657C134018914 @default.
• W2007767657 hasConceptScore W2007767657C170493617 @default.
• W2007767657 hasConceptScore W2007767657C180361614 @default.
• W2007767657 hasConceptScore W2007767657C185592680 @default.
• W2007767657 hasConceptScore W2007767657C2775960820 @default.
• W2007767657 hasConceptScore W2007767657C2778831791 @default.
• W2007767657 hasConceptScore W2007767657C2779395532 @default.
• W2007767657 hasConceptScore W2007767657C2781294074 @default.
• W2007767657 hasConceptScore W2007767657C2992686903 @default.
• W2007767657 hasConceptScore W2007767657C552990157 @default.
• W2007767657 hasConceptScore W2007767657C55493867 @default.
• W2007767657 hasConceptScore W2007767657C64241487 @default.
• W2007767657 hasConceptScore W2007767657C71924100 @default.
• W2007767657 hasConceptScore W2007767657C86803240 @default.
• W2007767657 hasIssue "1-2" @default.
• W2007767657 hasLocation W20077676571 @default.
• W2007767657 hasLocation W20077676572 @default.
• W2007767657 hasOpenAccess W2007767657 @default.
• W2007767657 hasPrimaryLocation W20077676571 @default.
• W2007767657 hasRelatedWork W2007767657 @default.
• W2007767657 hasRelatedWork W2057620757 @default.
• W2007767657 hasRelatedWork W2064061791 @default.
• W2007767657 hasRelatedWork W2080032097 @default.
• W2007767657 hasRelatedWork W2106480106 @default.

• next