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• W2007773281 startingPage "233" @default.
• W2007773281 abstract "Incorporation of modified nucleotides into DNA, using the PCR, has allowed us to probe the influence that the exocyclic 5-methyl group of pyrimidines has on DNAse I cleavage and sequence recognition by drugs. The results show that removal of the methyl group from the major groove, made possible by substituting uridine for thymidine, allows DNAse I to cleave more readily at AT-rich regions compared to normal DNA. By contrast, addition of an extra methyl group, contrived by substituting 5-methylcytidine for normal cytidine, allows DNAse I to cleave more readily at GC-rich regions compared to normal DNA. In the cutting pattern of DNA containing both uridine and 5-methyl cytosine, we find the cleavage characteristics of both the single-substituted DNA species combined. Thus, the presence or absence of the exocyclic 5-methyl group in the major groove has a strong influence on the relative intensity of cleavage of phosphodiester bonds by DNAse I. These nucleotide substitutions can also influence the sequence-selective binding of drugs to DNA. Whereas removal of the methyl group (replacement of T with U) generally has little effect on sequence recognition by a variety of drugs, addition of a methyl group (replacement of C with M) generates new binding sites for some intercalators, namely daunomycin, DACA and SN16713." @default.
• W2007773281 created "2016-06-24" @default.
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• W2007773281 date "1999-12-01" @default.
• W2007773281 modified "2023-09-25" @default.
• W2007773281 title "The influence of the exocyclic pyrimidine 5-methyl group on DNAse I cleavage and sequence recognition by drugs" @default.
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• W2007773281 doi "https://doi.org/10.1016/s0167-4781(99)00188-8" @default.
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