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• W2007777482 startingPage "165" @default.
• W2007777482 abstract "Maternal oxygen supplementation is commonly performed to improve fetal oxygenation and acid-base balance during fetal asphyxia. The efficiency of this treatment is controversial, which may be associated with the production of oxygen free radicals and lipid peroxidation. However, only a few studies have been performed to evaluate these issues. To clarify them, we investigated the effects of maternal oxygen supplementation on fetal oxygenation and lipid peroxidation following fetal asphyxia in late gestation goats. We measured fetal blood gases, pH and plasma malondialdehyde (MDA), one of the endproducts of lipid peroxidation, before, during and after fetal asphyxia with and without maternal oxygenation in late gestation goats. Fetal asphyxia was induced by a single total umbilical cord occlusion of 3 minutes' duration, and maternal oxygenation was initiated at 20 min before the cord occlusion and terminated at 20 min after the release of cord occlusion. Maternal oxygen supplementation resulted in a significant increase in fetal PaO(2) before and after the cord occlusion (p<0.05). During the cord occlusion, the extents of hypoxia and acidemia were not changed by maternal oxygen supplementation. Fetal plasma MDA levels before maternal oxygen supplementation averaged 0.80+/-0.04 micromol/L, significantly increased after the initiation of maternal oxygen supplementation (1.11+/-0.07 micromol/L), and further increased following fetal asphyxia (1.28+/-0.06 micromol/L), and after the release of the cord occlusion (1.58+/-0.7 micromol/L)(p<0.05). These values were significantly higher than those in fetuses without oxygenation. We conclude that maternal oxygen supplementation increased fetal oxygenation but caused a concomitant increase in lipid peroxidation in the fetus." @default.
• W2007777482 created "2016-06-24" @default.
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• W2007777482 date "2003-01-01" @default.
• W2007777482 modified "2023-10-14" @default.
• W2007777482 title "Effects of Maternal Oxygen Supplementation on Fetal Oxygenation and Lipid Peroxidation Following a Single Umbilical Cord Occlusion in Fetal Goats" @default.
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• W2007777482 doi "https://doi.org/10.1272/jnms.70.165" @default.
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