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• W2007796463 abstract "Significance How do N- and C-terminal flanking sequences from exon 1 of the huntingtin protein modulate the mechanisms of polyglutamine aggregation? We answer this question using approaches that combine distinct probes of aggregation mechanisms with measurements of solubility and aggregate morphologies. The N- and C-terminal flanking sequence modules from exon 1 of huntingtin act as gatekeepers, whereby the N-terminal flanking sequence accelerates fibril formation while destabilizing nonfibrillar species, whereas the C-terminal flanking sequence reduces the overall driving force for aggregation. These results provide a mechanistic underpinning for observations regarding naturally occurring sequence contexts as modulators of polyglutamine toxicity." @default.
• W2007796463 created "2016-06-24" @default.
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• W2007796463 date "2013-11-26" @default.
• W2007796463 modified "2023-10-18" @default.
• W2007796463 title "Unmasking the roles of N- and C-terminal flanking sequences from exon 1 of huntingtin as modulators of polyglutamine aggregation" @default.
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• W2007796463 doi "https://doi.org/10.1073/pnas.1320626110" @default.
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