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- W2007797163 abstract "Object: The aim of the present study was whether a combination of Pentosidine and carboxy-terminal telopeptide of type I collagen (I-CTP) can reliably risk stratify patients with preserved LV ejection fraction. Methods and Results: Serum levels of pentosidine and I-CTP were measured at admission in 150 consecutive patients hospitalized for chronic heart failure (CHF). Patients were divided into 2 groups based on the LV ejection fraction (LVEF): reduced LV systolic function group (LVEF < 50%, n = 67) and preserved LVEF group (LVEF > 50%, n = 83). Normal upper limits for Pentosidine and I-CTP values were determined from the receiver operating characteristic curves (35 ng/ml for Pentosidine and 5 pg/ml for I-CTP). In preserved LV ejection fraction group, a Cox regression hazard analysis demonstrated that Pentocidine (hazard ratio 1.009, p < 0.01) and I-CTP (hazard ratio 1.174, p < 0.05) were independent predictors of cardiac events. High concentrations of both Pentosidine and I-CTP at admission were associated with the highest incidence of cardiac events. Kaplan-Meier analysis also showed that the combination of Pentosidne and I-CTP concentrations could reliably stratify patients for cardiac events. Conclusion: Combined measurement of Pentosidine and I-CTP concentrations at admission may be a strongly reliable evaluation for risk stratifying CHF patients with preserved LVEF." @default.
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- W2007797163 date "2010-09-01" @default.
- W2007797163 modified "2023-09-27" @default.
- W2007797163 title "Combination of Pentosidine and I-CTP Strongly Predicts Cardiac Events in Heart Failure Patients With Preserved Left Ventricular Ejection Fraction" @default.
- W2007797163 doi "https://doi.org/10.1016/j.cardfail.2010.07.190" @default.
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