FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007804596> ?p ?o ?g. }

• W2007804596 endingPage "63" @default.
• W2007804596 startingPage "57" @default.
• W2007804596 abstract "OBJECTIVE This study was designed to determine the response to therapy using human chorionic gonadotrophin (hCG) and human menopausal gonadotrophin (hMG) in males with idiopathic isolated hypogonadotrophic hypogonadism (IHH), and to compare the responses in patients presenting with and without cryptorchidism. DESIGN Analysis of male patients with IHH treated with hCG or combined hCG/hMG for a minimum of 6 months at St Bartholomew's Hospital. Clinical and endocrine assessment was performed in all patients prior to commencing therapy. PATIENTS A total of 26 males with IHH have been treated with exogenous gonadotrophins. Thirteen patients (Group 1) had cryptorchidism (unilateral in 7, bilateral in 6) at presentation, and 13 (Group 2) did not. MEASUREMENTS All patients had basal serum testosterone, LH and FSH determinations. An i.v. GnRH test was performed in 25 patients and an i.m. hCG stimulation test in 19. Testicular volume and serum testosterone were measured during both hCG and combined hCG/hMG therapy. Seminal analysis was performed at the start and monthly during hCG/hMG therapy. RESULTS Eighty-five per cent of the 13 patients in Group 1 had an olfactory defect (Kallmann's syndrome), compared with 23% of Group 2. Both groups of patients showed a subnormal response to initial i.v. GnRH and i.m. hCG testing. During hCG therapy only three patients in Group 1 and six In Group 2 achieved normal adult testosterone levels. The non-cryptorchid group achieved a higher mean testicular volume on hCG therapy than the cryptorchid group (mean (SD); 4.7 (1.8) ml vs 3.0 (1.6) ml (P < 0.02)), and for all patients there was a correlation between initial and maximal testicular volume (R = 0.69, P = 0.001). Four patients in Group 1 and five patients in Group 2 were treated with combined hCG/hMG tor 6–15 months to induce fertility; only one patient in Group 1 achieved spermatogenesis, compared to all patients in Group 2 (leading to three pregnancies). CONCLUSIONS These data indicate that patients with idiopathic hypogonadotrophic hypogonadism (IHH) have a poor response to hCG therapy in terms of testicular growth and normalization of serum testosterone. Final testicular volume is dependent on Initial testicular size. In addition, patients with IHH associated with cryptorchidism have a poor fertility potential to combined hCG/hMG therapy." @default.
• W2007804596 created "2016-06-24" @default.
• W2007804596 creator A5009222811 @default.
• W2007804596 creator A5010422931 @default.
• W2007804596 creator A5020322879 @default.
• W2007804596 creator A5041774394 @default.
• W2007804596 creator A5045829884 @default.
• W2007804596 date "1994-07-01" @default.
• W2007804596 modified "2023-10-02" @default.
• W2007804596 title "Gonadal function and response to human chorionic and menopausal gonadotrophin therapy in male patients with idiopathic hypogonadotrophic hypogonadism" @default.
• W2007804596 cites W156370210 @default.
• W2007804596 cites W1987979860 @default.
• W2007804596 cites W1994020166 @default.
• W2007804596 cites W1998516976 @default.
• W2007804596 cites W2015960966 @default.
• W2007804596 cites W2017924854 @default.
• W2007804596 cites W2019344761 @default.
• W2007804596 cites W2024727717 @default.
• W2007804596 cites W2044092811 @default.
• W2007804596 cites W2067167997 @default.
• W2007804596 cites W2070173371 @default.
• W2007804596 cites W2086140240 @default.
• W2007804596 cites W2110244056 @default.
• W2007804596 cites W2117225481 @default.
• W2007804596 cites W2141712005 @default.
• W2007804596 cites W2312187890 @default.
• W2007804596 cites W2341203038 @default.
• W2007804596 cites W2408558081 @default.
• W2007804596 cites W3123006232 @default.
• W2007804596 cites W74707630 @default.
• W2007804596 doi "https://doi.org/10.1111/j.1365-2265.1994.tb03785.x" @default.
• W2007804596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7914153" @default.
• W2007804596 hasPublicationYear "1994" @default.
• W2007804596 type Work @default.
• W2007804596 sameAs 2007804596 @default.
• W2007804596 citedByCount "51" @default.
• W2007804596 countsByYear W20078045962012 @default.
• W2007804596 countsByYear W20078045962013 @default.
• W2007804596 countsByYear W20078045962014 @default.
• W2007804596 countsByYear W20078045962015 @default.
• W2007804596 countsByYear W20078045962016 @default.
• W2007804596 countsByYear W20078045962019 @default.
• W2007804596 countsByYear W20078045962020 @default.
• W2007804596 countsByYear W20078045962021 @default.
• W2007804596 countsByYear W20078045962022 @default.
• W2007804596 countsByYear W20078045962023 @default.
• W2007804596 crossrefType "journal-article" @default.
• W2007804596 hasAuthorship W2007804596A5009222811 @default.
• W2007804596 hasAuthorship W2007804596A5010422931 @default.
• W2007804596 hasAuthorship W2007804596A5020322879 @default.
• W2007804596 hasAuthorship W2007804596A5041774394 @default.
• W2007804596 hasAuthorship W2007804596A5045829884 @default.
• W2007804596 hasConcept C126322002 @default.
• W2007804596 hasConcept C134018914 @default.
• W2007804596 hasConcept C2775948956 @default.
• W2007804596 hasConcept C2776354409 @default.
• W2007804596 hasConcept C2777239080 @default.
• W2007804596 hasConcept C2777702977 @default.
• W2007804596 hasConcept C2778782382 @default.
• W2007804596 hasConcept C2779134260 @default.
• W2007804596 hasConcept C2779279991 @default.
• W2007804596 hasConcept C2781230225 @default.
• W2007804596 hasConcept C2781255401 @default.
• W2007804596 hasConcept C2909827854 @default.
• W2007804596 hasConcept C2910268463 @default.
• W2007804596 hasConcept C3008058167 @default.
• W2007804596 hasConcept C46699223 @default.
• W2007804596 hasConcept C524204448 @default.
• W2007804596 hasConcept C71315377 @default.
• W2007804596 hasConcept C71924100 @default.
• W2007804596 hasConceptScore W2007804596C126322002 @default.
• W2007804596 hasConceptScore W2007804596C134018914 @default.
• W2007804596 hasConceptScore W2007804596C2775948956 @default.
• W2007804596 hasConceptScore W2007804596C2776354409 @default.
• W2007804596 hasConceptScore W2007804596C2777239080 @default.
• W2007804596 hasConceptScore W2007804596C2777702977 @default.
• W2007804596 hasConceptScore W2007804596C2778782382 @default.
• W2007804596 hasConceptScore W2007804596C2779134260 @default.
• W2007804596 hasConceptScore W2007804596C2779279991 @default.
• W2007804596 hasConceptScore W2007804596C2781230225 @default.
• W2007804596 hasConceptScore W2007804596C2781255401 @default.
• W2007804596 hasConceptScore W2007804596C2909827854 @default.
• W2007804596 hasConceptScore W2007804596C2910268463 @default.
• W2007804596 hasConceptScore W2007804596C3008058167 @default.
• W2007804596 hasConceptScore W2007804596C46699223 @default.
• W2007804596 hasConceptScore W2007804596C524204448 @default.
• W2007804596 hasConceptScore W2007804596C71315377 @default.
• W2007804596 hasConceptScore W2007804596C71924100 @default.
• W2007804596 hasIssue "1" @default.
• W2007804596 hasLocation W20078045961 @default.
• W2007804596 hasLocation W20078045962 @default.
• W2007804596 hasOpenAccess W2007804596 @default.
• W2007804596 hasPrimaryLocation W20078045961 @default.
• W2007804596 hasRelatedWork W2004078550 @default.
• W2007804596 hasRelatedWork W2007804596 @default.
• W2007804596 hasRelatedWork W2023835522 @default.
• W2007804596 hasRelatedWork W2041241005 @default.
• W2007804596 hasRelatedWork W2053247908 @default.

• next