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• W2007805079 abstract "Abstract Cell tracking using perfluorocarbon labels and fluorine‐19 ( 19 F) MRI is a noninvasive approach to visualize and quantify cell populations in vivo. In this study, we investigated three‐dimensional compressed sensing methods to accelerate 19 F MRI data acquisition for cell tracking and evaluate the impact of acceleration on 19 F signal quantification. We show that a greater than 8‐fold reduction in imaging time was feasible without pronounced image degradation and with minimal impact on the image signal‐to‐noise ratio and 19 F quantification accuracy. In 19 F phantom studies, we show that apparent feature topology is maintained with compressed sensing reconstruction, and false positive signals do not appear in areas devoid of fluorine. We apply the three‐dimensional compressed sensing 19 F MRI methods to quantify the macrophage burden in a localized wounding‐inflammation mouse model in vivo; at 8‐fold image acceleration, the 19 F signal distribution was accurately reproduced, with no loss in signal‐to‐noise ratio. Our results demonstrate that three‐dimensional compressed sensing methods have potential for advancing in vivo 19 F cell tracking for a wide range of preclinical and translational applications. Magn Reson Med, 2013. © 2012 Wiley Periodicals, Inc." @default.
• W2007805079 created "2016-06-24" @default.
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• W2007805079 date "2012-07-26" @default.
• W2007805079 modified "2023-10-16" @default.
• W2007805079 title "Accelerated fluorine-19 MRI cell tracking using compressed sensing" @default.
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• W2007805079 doi "https://doi.org/10.1002/mrm.24414" @default.
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