Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007805774> ?p ?o ?g. }
- W2007805774 endingPage "173" @default.
- W2007805774 startingPage "167" @default.
- W2007805774 abstract "Homologous recombination (HR) occurs in all organisms, and is important for repair of DNA damage, chromosome segregation during meiosis, and genetic diversification. Genes critical for recombinational DNA repair and meiotic recombination include members of the RecA/RAD51 family, of which seven have been identified in mammals. Here, we describe the disruption of Rad51d (recently designated Rad51l3) in mice and its phenotypic consequences. Rad51d-deficient mice die between 8.5 and 11.5 dpc. The affected embryos are smaller than littermates, posteriorly truncated, and developmentally delayed. Embryonic fibroblasts from mutant embryos could not be propagated more than one generation in culture. Rad51d-deficient blastocysts were not sensitive to gamma radiation or methylmethanesulfonate (MMS) in blastocyst outgrowth experiments. The variable and generalized developmental progression defects in Rad51d-deficient embryos suggests that mutant cells may undergo delayed or suboptimal repair of DNA damage, resulting in accumulated degrees of mutation and/or cell cycle perturbation that are incompatible with normal embryonic development. genesis 26:167-173, 2000." @default.
- W2007805774 created "2016-06-24" @default.
- W2007805774 creator A5050520587 @default.
- W2007805774 creator A5069013040 @default.
- W2007805774 date "2000-03-01" @default.
- W2007805774 modified "2023-10-13" @default.
- W2007805774 title "Midgestation lethality in mice deficient for the RecA-related gene,Rad51d/Rad51l3" @default.
- W2007805774 cites W124504601 @default.
- W2007805774 cites W1660787335 @default.
- W2007805774 cites W1972710550 @default.
- W2007805774 cites W1980666758 @default.
- W2007805774 cites W1986974099 @default.
- W2007805774 cites W1987850577 @default.
- W2007805774 cites W1988845313 @default.
- W2007805774 cites W2002395343 @default.
- W2007805774 cites W2011881129 @default.
- W2007805774 cites W2012116939 @default.
- W2007805774 cites W2012300945 @default.
- W2007805774 cites W2017351036 @default.
- W2007805774 cites W2018299474 @default.
- W2007805774 cites W2025534396 @default.
- W2007805774 cites W2031705524 @default.
- W2007805774 cites W2031743305 @default.
- W2007805774 cites W2032907237 @default.
- W2007805774 cites W2034562158 @default.
- W2007805774 cites W2038275315 @default.
- W2007805774 cites W2039810557 @default.
- W2007805774 cites W2041761000 @default.
- W2007805774 cites W2052521064 @default.
- W2007805774 cites W2054000227 @default.
- W2007805774 cites W2054123861 @default.
- W2007805774 cites W2056508303 @default.
- W2007805774 cites W2059365987 @default.
- W2007805774 cites W2061151099 @default.
- W2007805774 cites W2065777930 @default.
- W2007805774 cites W2074732853 @default.
- W2007805774 cites W2088909687 @default.
- W2007805774 cites W2091350790 @default.
- W2007805774 cites W2098126099 @default.
- W2007805774 cites W2099251067 @default.
- W2007805774 cites W2099675208 @default.
- W2007805774 cites W2101710059 @default.
- W2007805774 cites W2101834361 @default.
- W2007805774 cites W2103770333 @default.
- W2007805774 cites W2109456034 @default.
- W2007805774 cites W2113739601 @default.
- W2007805774 cites W2121887331 @default.
- W2007805774 cites W2123879020 @default.
- W2007805774 cites W2128370098 @default.
- W2007805774 cites W2139554694 @default.
- W2007805774 cites W2141509764 @default.
- W2007805774 cites W2147755808 @default.
- W2007805774 cites W2157269460 @default.
- W2007805774 cites W2168460045 @default.
- W2007805774 cites W2168809955 @default.
- W2007805774 cites W2172916891 @default.
- W2007805774 cites W36644418 @default.
- W2007805774 cites W4322701626 @default.
- W2007805774 doi "https://doi.org/10.1002/(sici)1526-968x(200003)26:3<167::aid-gene1>3.0.co;2-m" @default.
- W2007805774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10705376" @default.
- W2007805774 hasPublicationYear "2000" @default.
- W2007805774 type Work @default.
- W2007805774 sameAs 2007805774 @default.
- W2007805774 citedByCount "146" @default.
- W2007805774 countsByYear W20078057742012 @default.
- W2007805774 countsByYear W20078057742013 @default.
- W2007805774 countsByYear W20078057742014 @default.
- W2007805774 countsByYear W20078057742015 @default.
- W2007805774 countsByYear W20078057742016 @default.
- W2007805774 countsByYear W20078057742017 @default.
- W2007805774 countsByYear W20078057742018 @default.
- W2007805774 countsByYear W20078057742019 @default.
- W2007805774 countsByYear W20078057742020 @default.
- W2007805774 countsByYear W20078057742021 @default.
- W2007805774 countsByYear W20078057742022 @default.
- W2007805774 countsByYear W20078057742023 @default.
- W2007805774 crossrefType "journal-article" @default.
- W2007805774 hasAuthorship W2007805774A5050520587 @default.
- W2007805774 hasAuthorship W2007805774A5069013040 @default.
- W2007805774 hasConcept C101434241 @default.
- W2007805774 hasConcept C102744134 @default.
- W2007805774 hasConcept C104317684 @default.
- W2007805774 hasConcept C134935766 @default.
- W2007805774 hasConcept C143065580 @default.
- W2007805774 hasConcept C143425029 @default.
- W2007805774 hasConcept C145103041 @default.
- W2007805774 hasConcept C148196450 @default.
- W2007805774 hasConcept C156695909 @default.
- W2007805774 hasConcept C196843134 @default.
- W2007805774 hasConcept C2778177303 @default.
- W2007805774 hasConcept C2779012473 @default.
- W2007805774 hasConcept C54355233 @default.
- W2007805774 hasConcept C552990157 @default.
- W2007805774 hasConcept C86803240 @default.
- W2007805774 hasConcept C87073359 @default.
- W2007805774 hasConcept C95444343 @default.
- W2007805774 hasConceptScore W2007805774C101434241 @default.
- W2007805774 hasConceptScore W2007805774C102744134 @default.