FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007807680> ?p ?o ?g. }

• W2007807680 endingPage "124" @default.
• W2007807680 startingPage "115" @default.
• W2007807680 abstract "Chemotherapy is an important approach for clinical cancer treatment. However, the success of chemotherapy is usually hindered by the occurrence of intrinsic or acquired multidrug resistance of cancer cells. Herein, we reported an effective approach to overcome doxorubicin (DOX) resistance in MCF-7/ADR breast cancer using DOX-loaded pH-responsive micelles. The micelles were prepared from a pH-responsive diblock copolymer, poly(ethylene glycol)-block-poly(2-(diisopropylamino)ethyl methacrylate) (PEG-b-PDPA), and a vitamin E derivate (D-α-tocopheryl polyethylene glycol 1000 succinate, TPGS) (denoted as PDPA/TPGS micelles). At neutral pH of 7.4, DOX was loaded into the hydrophobic core of PDPA/TPGS micelles via a film sonication method. After cellular uptake, the DOX payload was released in early endosomes by acidic pH-triggered micelle dissociation. Meanwhile, the TPGS component synergistically improved the cytotoxicity of DOX by targeting mitochondrial organelles and reducing the mitochondrial transmembrane potential. In vitro cell culture experiments using DOX-resistant MCF-7/ADR cells demonstrated that PDPA/TPGS micelles reduced the IC50 of DOX by a sixfold magnitude. In vivo animal studies showed that DOX-loaded PDPA/TPGS micelles (PDPA/TPGS@DOX) inhibited tumor growth more efficiently than free DOX in a nude mouse model bearing orthotopic MCF-7/ADR tumor. All these results imply that the mitochondria-targeted pH-responsive PDPA/TPGS micelles have significant potential for efficiently combating DOX resistance in breast cancer cells." @default.
• W2007807680 created "2016-06-24" @default.
• W2007807680 creator A5005200419 @default.
• W2007807680 creator A5022118078 @default.
• W2007807680 creator A5025007943 @default.
• W2007807680 creator A5029849389 @default.
• W2007807680 creator A5030409288 @default.
• W2007807680 creator A5045530029 @default.
• W2007807680 creator A5075381468 @default.
• W2007807680 creator A5077586136 @default.
• W2007807680 creator A5081175631 @default.
• W2007807680 creator A5090991197 @default.
• W2007807680 date "2015-03-01" @default.
• W2007807680 modified "2023-10-16" @default.
• W2007807680 title "Reversal of doxorubicin resistance in breast cancer by mitochondria-targeted pH-responsive micelles" @default.
• W2007807680 cites W1956617916 @default.
• W2007807680 cites W1965239527 @default.
• W2007807680 cites W1965636780 @default.
• W2007807680 cites W1977116179 @default.
• W2007807680 cites W1998149716 @default.
• W2007807680 cites W2005496979 @default.
• W2007807680 cites W2006434892 @default.
• W2007807680 cites W2021789618 @default.
• W2007807680 cites W2037128514 @default.
• W2007807680 cites W2044169155 @default.
• W2007807680 cites W2046785634 @default.
• W2007807680 cites W2048617277 @default.
• W2007807680 cites W2051950678 @default.
• W2007807680 cites W2055904567 @default.
• W2007807680 cites W2059623168 @default.
• W2007807680 cites W2061248454 @default.
• W2007807680 cites W2079641266 @default.
• W2007807680 cites W2081571363 @default.
• W2007807680 cites W2084769078 @default.
• W2007807680 cites W2088453496 @default.
• W2007807680 cites W2093226236 @default.
• W2007807680 cites W2106878843 @default.
• W2007807680 cites W2116364594 @default.
• W2007807680 cites W2138734774 @default.
• W2007807680 cites W2139100782 @default.
• W2007807680 cites W2144277227 @default.
• W2007807680 cites W2161859769 @default.
• W2007807680 cites W2318605753 @default.
• W2007807680 cites W2324775542 @default.
• W2007807680 cites W2325038060 @default.
• W2007807680 cites W4234381551 @default.
• W2007807680 doi "https://doi.org/10.1016/j.actbio.2014.12.001" @default.
• W2007807680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25498306" @default.
• W2007807680 hasPublicationYear "2015" @default.
• W2007807680 type Work @default.
• W2007807680 sameAs 2007807680 @default.
• W2007807680 citedByCount "107" @default.
• W2007807680 countsByYear W20078076802015 @default.
• W2007807680 countsByYear W20078076802016 @default.
• W2007807680 countsByYear W20078076802017 @default.
• W2007807680 countsByYear W20078076802018 @default.
• W2007807680 countsByYear W20078076802019 @default.
• W2007807680 countsByYear W20078076802020 @default.
• W2007807680 countsByYear W20078076802021 @default.
• W2007807680 countsByYear W20078076802022 @default.
• W2007807680 countsByYear W20078076802023 @default.
• W2007807680 crossrefType "journal-article" @default.
• W2007807680 hasAuthorship W2007807680A5005200419 @default.
• W2007807680 hasAuthorship W2007807680A5022118078 @default.
• W2007807680 hasAuthorship W2007807680A5025007943 @default.
• W2007807680 hasAuthorship W2007807680A5029849389 @default.
• W2007807680 hasAuthorship W2007807680A5030409288 @default.
• W2007807680 hasAuthorship W2007807680A5045530029 @default.
• W2007807680 hasAuthorship W2007807680A5075381468 @default.
• W2007807680 hasAuthorship W2007807680A5077586136 @default.
• W2007807680 hasAuthorship W2007807680A5081175631 @default.
• W2007807680 hasAuthorship W2007807680A5090991197 @default.
• W2007807680 hasConcept C10138342 @default.
• W2007807680 hasConcept C109316439 @default.
• W2007807680 hasConcept C11268172 @default.
• W2007807680 hasConcept C121608353 @default.
• W2007807680 hasConcept C12554922 @default.
• W2007807680 hasConcept C150903083 @default.
• W2007807680 hasConcept C162324750 @default.
• W2007807680 hasConcept C178790620 @default.
• W2007807680 hasConcept C184651966 @default.
• W2007807680 hasConcept C185592680 @default.
• W2007807680 hasConcept C192562407 @default.
• W2007807680 hasConcept C202751555 @default.
• W2007807680 hasConcept C207001950 @default.
• W2007807680 hasConcept C2776694085 @default.
• W2007807680 hasConcept C2776964284 @default.
• W2007807680 hasConcept C2777516009 @default.
• W2007807680 hasConcept C2781303535 @default.
• W2007807680 hasConcept C54355233 @default.
• W2007807680 hasConcept C54400483 @default.
• W2007807680 hasConcept C55493867 @default.
• W2007807680 hasConcept C86803240 @default.
• W2007807680 hasConcept C96232424 @default.
• W2007807680 hasConcept C98274493 @default.
• W2007807680 hasConceptScore W2007807680C10138342 @default.
• W2007807680 hasConceptScore W2007807680C109316439 @default.
• W2007807680 hasConceptScore W2007807680C11268172 @default.

• next