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- W2007807897 abstract "Culture of human B lymphocytes with polyclonally activating surrogates for type II T-cell-independent antigen, i.e., anti-IgM mAb and anti-IgM:dextran, resulted in both membrane IgM (mIgM)-triggered S/G2/M entry and apoptosis. Although high ligand valency could compensate for low affinity, and high affinity could compensate for low valency, in achieving mIgM-triggered apoptosis, the phenomenon was most pronounced when the soluble “antigen” had both high binding site affinity and valency. Most of the mIgM-triggered apoptosis may represent B cells which progress into G1but fail to receive a sufficient level of continuous mIgM-mediated signaling during G1for passage through a G1→ S phase restriction point(s). This was supported by the findings that (a) a lesser proportion of mIg-triggered cells enter S phase than G1; (b) maximal mIgM-triggered apoptosis was noted at 48–72 h of culture and surrounding activated cell clusters; (c) mIgM-triggered apoptosis was not inhibited by pharmacologic blockers of S phase; and (d) a high proportion of viable mIgM-triggered B cell blasts in G1succumb to apoptosis rather than enter S phase, if high-affinity multivalent ligand is washed from the cultures. In addition to quantitative aspects of initial receptor engagement, the potential for a protracted period of recurrent mIgM signaling events may influence whether apoptosis or cell cycle progression is the functional outcome of B cell encounter with a multivalent antigen." @default.
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- W2007807897 date "1998-09-01" @default.
- W2007807897 modified "2023-09-27" @default.
- W2007807897 title "Membrane IgM-Stimulated Human B Lymphocytes Succumb to Activation-Related Apoptosis at a G1→ S Transition: Influence of Ligand Affinity and Valency" @default.
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- W2007807897 doi "https://doi.org/10.1006/cimm.1998.1359" @default.
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