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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007809227> ?p ?o ?g. }

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• W2007809227 abstract "For virulence and transmission, the protozoan parasite Leishmania must assemble a complex glycolipid on the cell surface, the lipophosphoglycan (LPG). Functional complementation identified the gene LPG2, which encodes an integral Golgi membrane protein implicated in intracellular compartmentalization of LPG biosynthesis. Ipg2- mutants lack only characteristic disaccharide-phosphate repeats, normally present on both LPG and other surface or secreted molecules considered critical for infectivity. In contrast, a related yeast gene, VAN2/VRG4, is essential and required for general Golgi function. These results suggest that LPG2participates in a specialized virulence pathway, which may offer an attractive target for chemotherapy." @default.
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• W2007809227 date "1995-09-29" @default.
• W2007809227 modified "2023-09-23" @default.
• W2007809227 title "A Specialized Pathway Affecting Virulence Glycoconjugates of<i>Leishmania</i>" @default.
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• W2007809227 doi "https://doi.org/10.1126/science.7569927" @default.
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