FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007812753> ?p ?o ?g. }

• W2007812753 endingPage "295" @default.
• W2007812753 startingPage "289" @default.
• W2007812753 abstract "Primary genetic factors are etiologic in at least 5–10% of patients with colon cancer. The polyposis syndromes (FPC) are easily identified examples because of the spectacular number of polyps. The hereditary nonpolyposis syndromes (HNPCC), although five times more common than FPC, arc usually not recognized because they do not have such a distinctive clinical, premonitory genetic marker. Colorectal cancer expression was surveyed in 10 extended, thoroughly documented HNPCC kindreds. One hundred sixteen patients were found to have 183 colorectal cancers. Despite the striking family history, less than 5% were correctly treated by subtotal colectomy. This provided a unique opportunity to study the natural history. Five findings differed significantly (p < 0.05) from patients with sporadic colon cancer: (1) mean age of initial colon cancer diagnosed was 45.6 years; (2) 69.1% of first colon cancers were located proximal to the splenic flexure of the colon; (3) 18.1% had synchronous colon cancer; (4) 24.2% had metachronous colon cancer develop with life table analysis showing the risk for a metachronous lesion at 10 years to be 40%; and (5) only 23.3% of cancers were located in the sigmoid colon or rectum. Based on this data, it is recommended that the family history of all patients with a newly diagnosed colon cancer be evaluated for evidence of this syndrome. If an autosomal dominant inheritance pattern emerges, an in-depth genetic investigation is indicated. When HNPCC is confirmed, the following recommendations apply: a subtotal abdominal colectomy is indicated at the time of the initial colon cancer because of the risk of synchronous and metachronous lesions. The rectum should be spared in favor of careful lifetime surveillance because of the proclivity for proximal colon cancer involvement. As yet unaffected members of a newly diagnosed HNPCC kindred who are in the “direct genetic line” should be cautioned that they are at 50% risk and must begin an intensive surveillance program beginning in the third decade with careful attention to the right colon. Patients from newly diagnosed HNPCC families who have had a previous conventional colectomy for colon cancer should, at the very least, enter an intensive surveillance program; a prophylactic completion subtotal colectomy should be considered for patients who arc less than totally compliant." @default.
• W2007812753 created "2016-06-24" @default.
• W2007812753 creator A5010712504 @default.
• W2007812753 creator A5026431708 @default.
• W2007812753 creator A5029960276 @default.
• W2007812753 creator A5049580044 @default.
• W2007812753 creator A5050161667 @default.
• W2007812753 creator A5050320028 @default.
• W2007812753 creator A5051859145 @default.
• W2007812753 creator A5057624100 @default.
• W2007812753 creator A5084172703 @default.
• W2007812753 date "1987-09-01" @default.
• W2007812753 modified "2023-10-16" @default.
• W2007812753 title "Recognition and Treatment of Patients with Hereditary Nonpolyposis Colon Cancer (Lynch Syndromes I and II)" @default.
• W2007812753 cites W1491358142 @default.
• W2007812753 cites W1500288385 @default.
• W2007812753 cites W1989139813 @default.
• W2007812753 cites W1992345181 @default.
• W2007812753 cites W2044176483 @default.
• W2007812753 cites W2191971350 @default.
• W2007812753 cites W2323899819 @default.
• W2007812753 cites W2409396953 @default.
• W2007812753 doi "https://doi.org/10.1097/00000658-198709000-00007" @default.
• W2007812753 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1493182" @default.
• W2007812753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3632093" @default.
• W2007812753 hasPublicationYear "1987" @default.
• W2007812753 type Work @default.
• W2007812753 sameAs 2007812753 @default.
• W2007812753 citedByCount "198" @default.
• W2007812753 countsByYear W20078127532012 @default.
• W2007812753 countsByYear W20078127532013 @default.
• W2007812753 countsByYear W20078127532015 @default.
• W2007812753 countsByYear W20078127532016 @default.
• W2007812753 countsByYear W20078127532018 @default.
• W2007812753 countsByYear W20078127532019 @default.
• W2007812753 countsByYear W20078127532020 @default.
• W2007812753 countsByYear W20078127532021 @default.
• W2007812753 countsByYear W20078127532023 @default.
• W2007812753 crossrefType "journal-article" @default.
• W2007812753 hasAuthorship W2007812753A5010712504 @default.
• W2007812753 hasAuthorship W2007812753A5026431708 @default.
• W2007812753 hasAuthorship W2007812753A5029960276 @default.
• W2007812753 hasAuthorship W2007812753A5049580044 @default.
• W2007812753 hasAuthorship W2007812753A5050161667 @default.
• W2007812753 hasAuthorship W2007812753A5050320028 @default.
• W2007812753 hasAuthorship W2007812753A5051859145 @default.
• W2007812753 hasAuthorship W2007812753A5057624100 @default.
• W2007812753 hasAuthorship W2007812753A5084172703 @default.
• W2007812753 hasBestOaLocation W20078127532 @default.
• W2007812753 hasConcept C121608353 @default.
• W2007812753 hasConcept C126322002 @default.
• W2007812753 hasConcept C143998085 @default.
• W2007812753 hasConcept C2776667177 @default.
• W2007812753 hasConcept C2776870353 @default.
• W2007812753 hasConcept C2781074409 @default.
• W2007812753 hasConcept C2781179581 @default.
• W2007812753 hasConcept C526805850 @default.
• W2007812753 hasConcept C71924100 @default.
• W2007812753 hasConcept C90924648 @default.
• W2007812753 hasConceptScore W2007812753C121608353 @default.
• W2007812753 hasConceptScore W2007812753C126322002 @default.
• W2007812753 hasConceptScore W2007812753C143998085 @default.
• W2007812753 hasConceptScore W2007812753C2776667177 @default.
• W2007812753 hasConceptScore W2007812753C2776870353 @default.
• W2007812753 hasConceptScore W2007812753C2781074409 @default.
• W2007812753 hasConceptScore W2007812753C2781179581 @default.
• W2007812753 hasConceptScore W2007812753C526805850 @default.
• W2007812753 hasConceptScore W2007812753C71924100 @default.
• W2007812753 hasConceptScore W2007812753C90924648 @default.
• W2007812753 hasIssue "3" @default.
• W2007812753 hasLocation W20078127531 @default.
• W2007812753 hasLocation W20078127532 @default.
• W2007812753 hasLocation W20078127533 @default.
• W2007812753 hasOpenAccess W2007812753 @default.
• W2007812753 hasPrimaryLocation W20078127531 @default.
• W2007812753 hasRelatedWork W2044658514 @default.
• W2007812753 hasRelatedWork W2092319801 @default.
• W2007812753 hasRelatedWork W2108891940 @default.
• W2007812753 hasRelatedWork W2235371377 @default.
• W2007812753 hasRelatedWork W2417386786 @default.
• W2007812753 hasRelatedWork W2547480541 @default.
• W2007812753 hasRelatedWork W2791459494 @default.
• W2007812753 hasRelatedWork W3210791064 @default.
• W2007812753 hasRelatedWork W4290765115 @default.
• W2007812753 hasRelatedWork W4318616217 @default.
• W2007812753 hasVolume "206" @default.
• W2007812753 isParatext "false" @default.
• W2007812753 isRetracted "false" @default.
• W2007812753 magId "2007812753" @default.
• W2007812753 workType "article" @default.