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- W2007831270 abstract "To the Editor: A 38-yr-old male, ASA physical status II, with myotonic dystrophy presented for removal of orthopedic hardware from the lumbar spine. Midazolam, 1.0 mg, and fentanyl, 100 micro gram, were given intravenously. General anesthesia was induced with 200 mg propofol 2.5 mg/kg). Immediately after the propofol, the patient described pain in his right arm causing flexion of his right arm. After loss of consciousness, a sustained contracture occurred in the right arm and lasted approximately 20 s before spontaneously relaxing. Anesthesia, emergence, and recovery were uneventful. Myotonic dystrophy-associated anesthetic problems include sensitivity to induction agents, opioids, and nondepolarizing drugs [1]. Propofol, with its fast onset and recovery time, may be of benefit in patients with muscle disease and has been used in myotonic dystrophy without problems [2]. Generalized myotonia has been reported with the use of propofol in myotonic dystrophy [3]. We hypothesize focal myotonic contraction resulted from the pain associated with propofol stimulating flexion of the biceps, initiating the myotonic contraction. Administering intravenous lidocaine before propofol may prevent or limit propofol-associated focal myotonic contractions in patients with myotonic dystrophy. Michelle A. O. Kinney, MD Barry A. Harrison, MD Department of Anesthesiology Mayo Clinic and Foundation Rochester, MN 55905" @default.
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- W2007831270 title "Propofol-Induced Myotonia in Myotonic Dystrophy" @default.
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- W2007831270 doi "https://doi.org/10.1097/00000539-199609000-00067" @default.
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