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- W2007834603 abstract "The low numbers of hydrogen ions in physiological solutions encouraged the assumption that H(+) currents flowing through conductive pathways would be so small as to be unmeasurable even if theoretically possible. Evidence for an H(+)-based action potential in the luminescent dinoflagellate Noctiluca and for an H(+)-conducting channel created by the secretions of the bacterium Bacillus brevis, did little to alter this perception. The clear demonstration of H(+) conduction in molluscan neurons might have provided the breakthrough but the new pathway was without an easily demonstrable function, and escaped general attention. Indeed the extreme measures that must be taken to successfully isolate H(+) currents meant that it was some years before proton channels were identified in mammalian cells. However, with the general availability of patch-clamp techniques and evidence for an important role in mammalian neutrophils, the stage was set for a series of structure/function studies with the potential to make the proton channel the best understood channel of all. In addition, widespread genomic searches have established that proton channels play important roles in processes ranging from fertilization of the human ovum to the progression of breast cancer. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim." @default.
- W2007834603 created "2016-06-24" @default.
- W2007834603 creator A5016478912 @default.
- W2007834603 date "2012-08-06" @default.
- W2007834603 modified "2023-10-09" @default.
- W2007834603 title "A contribution to the history of the proton channel" @default.
- W2007834603 cites W1515146239 @default.
- W2007834603 cites W1540307815 @default.
- W2007834603 cites W1661187373 @default.
- W2007834603 cites W1913218967 @default.
- W2007834603 cites W1917503746 @default.
- W2007834603 cites W1958431711 @default.
- W2007834603 cites W1964126982 @default.
- W2007834603 cites W1964884778 @default.
- W2007834603 cites W1965191256 @default.
- W2007834603 cites W1965415704 @default.
- W2007834603 cites W1969848842 @default.
- W2007834603 cites W1970340548 @default.
- W2007834603 cites W1972959316 @default.
- W2007834603 cites W1973058160 @default.
- W2007834603 cites W1977263429 @default.
- W2007834603 cites W1977441756 @default.
- W2007834603 cites W1977979409 @default.
- W2007834603 cites W1979850758 @default.
- W2007834603 cites W1979979306 @default.
- W2007834603 cites W1982674781 @default.
- W2007834603 cites W1983523125 @default.
- W2007834603 cites W1985940938 @default.
- W2007834603 cites W1986209632 @default.
- W2007834603 cites W1989605789 @default.
- W2007834603 cites W1990667548 @default.
- W2007834603 cites W1992716102 @default.
- W2007834603 cites W1993586672 @default.
- W2007834603 cites W1994676579 @default.
- W2007834603 cites W1997086412 @default.
- W2007834603 cites W1999662654 @default.
- W2007834603 cites W2000045723 @default.
- W2007834603 cites W2000129051 @default.
- W2007834603 cites W2000456276 @default.
- W2007834603 cites W2003592718 @default.
- W2007834603 cites W2006404213 @default.
- W2007834603 cites W2006500391 @default.
- W2007834603 cites W2008470626 @default.
- W2007834603 cites W2012523642 @default.
- W2007834603 cites W2019778840 @default.
- W2007834603 cites W2019998982 @default.
- W2007834603 cites W2020359055 @default.
- W2007834603 cites W2021553390 @default.
- W2007834603 cites W2023571480 @default.
- W2007834603 cites W2024062901 @default.
- W2007834603 cites W2024801871 @default.
- W2007834603 cites W2025443689 @default.
- W2007834603 cites W2026468876 @default.
- W2007834603 cites W2029592445 @default.
- W2007834603 cites W2030441400 @default.
- W2007834603 cites W2031920967 @default.
- W2007834603 cites W2033387624 @default.
- W2007834603 cites W2034845112 @default.
- W2007834603 cites W2038206688 @default.
- W2007834603 cites W2038212991 @default.
- W2007834603 cites W2038723032 @default.
- W2007834603 cites W2038792242 @default.
- W2007834603 cites W2041836266 @default.
- W2007834603 cites W2042216906 @default.
- W2007834603 cites W2042362660 @default.
- W2007834603 cites W2042590680 @default.
- W2007834603 cites W2042914373 @default.
- W2007834603 cites W2044921719 @default.
- W2007834603 cites W2045120197 @default.
- W2007834603 cites W2046214522 @default.
- W2007834603 cites W2051488665 @default.
- W2007834603 cites W2053120786 @default.
- W2007834603 cites W2053316347 @default.
- W2007834603 cites W2054394491 @default.
- W2007834603 cites W2056948361 @default.
- W2007834603 cites W2058333657 @default.
- W2007834603 cites W2060422389 @default.
- W2007834603 cites W2061206540 @default.
- W2007834603 cites W2068032188 @default.
- W2007834603 cites W2069940579 @default.
- W2007834603 cites W2074083906 @default.
- W2007834603 cites W2079157916 @default.
- W2007834603 cites W2081299190 @default.
- W2007834603 cites W2083317271 @default.
- W2007834603 cites W2085949935 @default.
- W2007834603 cites W2086341327 @default.
- W2007834603 cites W2089414866 @default.
- W2007834603 cites W2089919723 @default.
- W2007834603 cites W2091890147 @default.
- W2007834603 cites W2100548210 @default.
- W2007834603 cites W2103566186 @default.
- W2007834603 cites W2103928042 @default.
- W2007834603 cites W2104206941 @default.
- W2007834603 cites W2107527293 @default.
- W2007834603 cites W2109610023 @default.
- W2007834603 cites W2112142299 @default.
- W2007834603 cites W2116280694 @default.
- W2007834603 cites W2122511716 @default.