Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007852298> ?p ?o ?g. }
- W2007852298 endingPage "10078" @default.
- W2007852298 startingPage "10068" @default.
- W2007852298 abstract "Aberrant aggregation of alpha-synuclein (alpha-syn) to form fibrils and insoluble aggregates has been implicated in the pathogenic processes of many neurodegenerative diseases. Despite the dramatic effects of dopamine in inhibiting the formation of alpha-syn fibrils by stabilization of oligomeric intermediates in cell-free systems, no studies have examined the effects of intracellular dopamine on alpha-syn aggregation. To study this process and its association with neurodegeneration, intracellular catechol levels were increased to various levels by expressing different forms of tyrosine hydroxylase, in cells induced to form alpha-syn aggregates. The increase in the steady-state dopamine levels inhibited the formation of alpha-syn aggregates and induced the formation of innocuous oligomeric intermediates. Analysis of transgenic mice expressing the disease-associated A53T mutant alpha-syn revealed the presence of oligomeric alpha-syn in nondegenerating dopaminergic neurons that do contain insoluble alpha-syn. These data indicate that intraneuronal dopamine levels can be a major modulator of alpha-syn aggregation and inclusion formation, with important implications on the selective degeneration of these neurons in Parkinson's disease." @default.
- W2007852298 created "2016-06-24" @default.
- W2007852298 creator A5004939550 @default.
- W2007852298 creator A5005020048 @default.
- W2007852298 creator A5009285584 @default.
- W2007852298 creator A5010542220 @default.
- W2007852298 creator A5055821313 @default.
- W2007852298 creator A5060360611 @default.
- W2007852298 creator A5066720282 @default.
- W2007852298 creator A5080558971 @default.
- W2007852298 creator A5084655691 @default.
- W2007852298 date "2006-09-27" @default.
- W2007852298 modified "2023-09-24" @default.
- W2007852298 title "Cytosolic Catechols Inhibit α-Synuclein Aggregation and Facilitate the Formation of Intracellular Soluble Oligomeric Intermediates" @default.
- W2007852298 cites W1490746857 @default.
- W2007852298 cites W1496790952 @default.
- W2007852298 cites W1502551601 @default.
- W2007852298 cites W1521854746 @default.
- W2007852298 cites W1527671059 @default.
- W2007852298 cites W1530609782 @default.
- W2007852298 cites W1572679174 @default.
- W2007852298 cites W1637321639 @default.
- W2007852298 cites W1709336739 @default.
- W2007852298 cites W1965778124 @default.
- W2007852298 cites W1968990406 @default.
- W2007852298 cites W1969366577 @default.
- W2007852298 cites W1970122257 @default.
- W2007852298 cites W1975188689 @default.
- W2007852298 cites W1976148085 @default.
- W2007852298 cites W1976345822 @default.
- W2007852298 cites W1982467499 @default.
- W2007852298 cites W1983967633 @default.
- W2007852298 cites W1989522802 @default.
- W2007852298 cites W1990868007 @default.
- W2007852298 cites W1996355944 @default.
- W2007852298 cites W2001407922 @default.
- W2007852298 cites W2004315433 @default.
- W2007852298 cites W2011332000 @default.
- W2007852298 cites W2018633688 @default.
- W2007852298 cites W2030602873 @default.
- W2007852298 cites W2037088901 @default.
- W2007852298 cites W2037460022 @default.
- W2007852298 cites W2042853579 @default.
- W2007852298 cites W2045130093 @default.
- W2007852298 cites W2059233213 @default.
- W2007852298 cites W2061995199 @default.
- W2007852298 cites W2068288454 @default.
- W2007852298 cites W2068602144 @default.
- W2007852298 cites W2073893553 @default.
- W2007852298 cites W2078589597 @default.
- W2007852298 cites W2080765656 @default.
- W2007852298 cites W2084910880 @default.
- W2007852298 cites W2086074591 @default.
- W2007852298 cites W2087389265 @default.
- W2007852298 cites W2091265794 @default.
- W2007852298 cites W2092791231 @default.
- W2007852298 cites W2103782048 @default.
- W2007852298 cites W2107434243 @default.
- W2007852298 cites W2123184492 @default.
- W2007852298 cites W2124405216 @default.
- W2007852298 cites W2130323165 @default.
- W2007852298 cites W2144435948 @default.
- W2007852298 cites W2150656456 @default.
- W2007852298 cites W2153441656 @default.
- W2007852298 cites W2161334375 @default.
- W2007852298 cites W2164327707 @default.
- W2007852298 cites W2171281715 @default.
- W2007852298 cites W2211987820 @default.
- W2007852298 cites W2315634470 @default.
- W2007852298 cites W4295994768 @default.
- W2007852298 doi "https://doi.org/10.1523/jneurosci.0896-06.2006" @default.
- W2007852298 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6674486" @default.
- W2007852298 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17005870" @default.
- W2007852298 hasPublicationYear "2006" @default.
- W2007852298 type Work @default.
- W2007852298 sameAs 2007852298 @default.
- W2007852298 citedByCount "143" @default.
- W2007852298 countsByYear W20078522982012 @default.
- W2007852298 countsByYear W20078522982013 @default.
- W2007852298 countsByYear W20078522982014 @default.
- W2007852298 countsByYear W20078522982015 @default.
- W2007852298 countsByYear W20078522982016 @default.
- W2007852298 countsByYear W20078522982017 @default.
- W2007852298 countsByYear W20078522982018 @default.
- W2007852298 countsByYear W20078522982019 @default.
- W2007852298 countsByYear W20078522982020 @default.
- W2007852298 countsByYear W20078522982021 @default.
- W2007852298 countsByYear W20078522982022 @default.
- W2007852298 countsByYear W20078522982023 @default.
- W2007852298 crossrefType "journal-article" @default.
- W2007852298 hasAuthorship W2007852298A5004939550 @default.
- W2007852298 hasAuthorship W2007852298A5005020048 @default.
- W2007852298 hasAuthorship W2007852298A5009285584 @default.
- W2007852298 hasAuthorship W2007852298A5010542220 @default.
- W2007852298 hasAuthorship W2007852298A5055821313 @default.
- W2007852298 hasAuthorship W2007852298A5060360611 @default.
- W2007852298 hasAuthorship W2007852298A5066720282 @default.
- W2007852298 hasAuthorship W2007852298A5080558971 @default.