Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007857130> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2007857130 endingPage "814" @default.
- W2007857130 startingPage "810" @default.
- W2007857130 abstract "Background: Chemotherapy-induced nausea and vomiting (CINV) is a debilitating side effect. Previous studies have primarily focused on prophylactic therapy, but no published reports have evaluated the treatment of breakthrough CINV. Methods: A prospective, pilot study was performed to provide preliminary prospective evidence of the efficacy of individual agents prescribed for the treatment of breakthrough CINV. Enrolled patients were receiving moderately or highly emetogenic chemotherapy and prophylactic treatment of CINV based on antiemetic guidelines. Patients were prescribed an antiemetic for breakthrough CINV at the discretion of their treating oncologist. If patients had breakthrough CINV that required a breakthrough antiemetic medication, they were instructed to complete a questionnaire every 30 minutes for 4 hours after taking the antiemetic. Levels of nausea (0–10), vomiting, and side effects were recorded. Results: Of the 96 patients enrolled, 27 (28%) reported breakthrough nausea and/or vomiting requiring medication and completed the questionniare. Eighty-eight percent (n = 24) reported the use of prochlorperazine; they experienced a 75% median nausea reduction after 4 hours, with minimal side effects. Three patients (12%) reported the use of a 5-hydroxytryptophan (5-HT) receptor antagonist for treatment of breakthrough nausea. These patients reported a median nausea reduction of 75% after 4 hours and no perceived toxicities. Conclusions: Prochlorperazine and 5-HT receptor antagonists appear to be effective breakthrough antiemetic therapies. The described study methodology can be used to conduct randomized clinical trials to find more effective drugs for treating established nausea." @default.
- W2007857130 created "2016-06-24" @default.
- W2007857130 creator A5008767553 @default.
- W2007857130 creator A5018264687 @default.
- W2007857130 creator A5027306320 @default.
- W2007857130 creator A5028702168 @default.
- W2007857130 creator A5034972183 @default.
- W2007857130 creator A5037783485 @default.
- W2007857130 date "2011-07-01" @default.
- W2007857130 modified "2023-09-24" @default.
- W2007857130 title "Antiemetics for Chemotherapy-Induced Nausea and Vomiting Occurring Despite Prophylactic Antiemetic Therapy" @default.
- W2007857130 cites W1561023139 @default.
- W2007857130 cites W1677064961 @default.
- W2007857130 cites W1997707842 @default.
- W2007857130 cites W2041576066 @default.
- W2007857130 cites W2049464048 @default.
- W2007857130 cites W2074318951 @default.
- W2007857130 cites W2116682901 @default.
- W2007857130 cites W2165972846 @default.
- W2007857130 cites W3012248373 @default.
- W2007857130 doi "https://doi.org/10.1089/jpm.2011.0058" @default.
- W2007857130 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3118930" @default.
- W2007857130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21554125" @default.
- W2007857130 hasPublicationYear "2011" @default.
- W2007857130 type Work @default.
- W2007857130 sameAs 2007857130 @default.
- W2007857130 citedByCount "27" @default.
- W2007857130 countsByYear W20078571302012 @default.
- W2007857130 countsByYear W20078571302013 @default.
- W2007857130 countsByYear W20078571302014 @default.
- W2007857130 countsByYear W20078571302015 @default.
- W2007857130 countsByYear W20078571302016 @default.
- W2007857130 countsByYear W20078571302017 @default.
- W2007857130 countsByYear W20078571302018 @default.
- W2007857130 countsByYear W20078571302019 @default.
- W2007857130 countsByYear W20078571302020 @default.
- W2007857130 countsByYear W20078571302021 @default.
- W2007857130 crossrefType "journal-article" @default.
- W2007857130 hasAuthorship W2007857130A5008767553 @default.
- W2007857130 hasAuthorship W2007857130A5018264687 @default.
- W2007857130 hasAuthorship W2007857130A5027306320 @default.
- W2007857130 hasAuthorship W2007857130A5028702168 @default.
- W2007857130 hasAuthorship W2007857130A5034972183 @default.
- W2007857130 hasAuthorship W2007857130A5037783485 @default.
- W2007857130 hasBestOaLocation W20078571302 @default.
- W2007857130 hasConcept C126322002 @default.
- W2007857130 hasConcept C2776694085 @default.
- W2007857130 hasConcept C2779924295 @default.
- W2007857130 hasConcept C2780580376 @default.
- W2007857130 hasConcept C2780852908 @default.
- W2007857130 hasConcept C2780884295 @default.
- W2007857130 hasConcept C2781324269 @default.
- W2007857130 hasConcept C42219234 @default.
- W2007857130 hasConcept C71924100 @default.
- W2007857130 hasConceptScore W2007857130C126322002 @default.
- W2007857130 hasConceptScore W2007857130C2776694085 @default.
- W2007857130 hasConceptScore W2007857130C2779924295 @default.
- W2007857130 hasConceptScore W2007857130C2780580376 @default.
- W2007857130 hasConceptScore W2007857130C2780852908 @default.
- W2007857130 hasConceptScore W2007857130C2780884295 @default.
- W2007857130 hasConceptScore W2007857130C2781324269 @default.
- W2007857130 hasConceptScore W2007857130C42219234 @default.
- W2007857130 hasConceptScore W2007857130C71924100 @default.
- W2007857130 hasIssue "7" @default.
- W2007857130 hasLocation W20078571301 @default.
- W2007857130 hasLocation W20078571302 @default.
- W2007857130 hasLocation W20078571303 @default.
- W2007857130 hasLocation W20078571304 @default.
- W2007857130 hasOpenAccess W2007857130 @default.
- W2007857130 hasPrimaryLocation W20078571301 @default.
- W2007857130 hasRelatedWork W1974541163 @default.
- W2007857130 hasRelatedWork W2003697710 @default.
- W2007857130 hasRelatedWork W2007857130 @default.
- W2007857130 hasRelatedWork W2014425593 @default.
- W2007857130 hasRelatedWork W2033327063 @default.
- W2007857130 hasRelatedWork W2080135046 @default.
- W2007857130 hasRelatedWork W2119857165 @default.
- W2007857130 hasRelatedWork W2512888629 @default.
- W2007857130 hasRelatedWork W2611083795 @default.
- W2007857130 hasRelatedWork W2768346972 @default.
- W2007857130 hasVolume "14" @default.
- W2007857130 isParatext "false" @default.
- W2007857130 isRetracted "false" @default.
- W2007857130 magId "2007857130" @default.
- W2007857130 workType "article" @default.