FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007859115> ?p ?o ?g. }

• W2007859115 endingPage "68" @default.
• W2007859115 startingPage "58" @default.
• W2007859115 abstract "Apart from activation of the brain reward system, cocaine administration influences the activity of the hypothalamo-pituitary-adrenal (HPA) axis by affecting CRH neurons in the paraventricular nucleus of the hypothalamus (PVN). In order to find a molecular mechanism of cocaine-evoked effects in the PVN, in the present study, we investigated the impact of cocaine on the expression of FosB/DeltaFosB transcription factors in the PVN. Using an immunohistochemical method, we found that acute cocaine treatment (25 mg/kg) induced a relatively long-lasting (at least 72 h) expression of FosB/DeltaFosB in the PVN, whereas repeated cocaine administration (25 mg/kg, once daily for 5 consecutive days) caused accumulation of FosB/DeltaFosB in the PVN. The latter observation was further confirmed by the Western blot technique which revealed that repeated exposure to cocaine specifically increased the expression of a stable isoform of DeltaFosB (35 kDa). Using a double-labeling immunofluorescent method, it was established that FosB/DeltaFosB proteins induced by repeated cocaine treatment were present in a small population of CRF-immunoreactive neurons of the PVN. Furthermore, it was found that pretreatment with the specific antagonist of dopamine D1-like receptors SCH 23390 (1 mg/kg) attenuated the expression and accumulation of FosB/DeltaFosB in the PVN, evoked by repeated cocaine administration. Although functional consequences of the above effects for the process of addiction remain to be established, the obtained results indicate that cocaine administration can produce relatively long-lasting changes in the expression of FosB/DeltaFosB transcription factors in PVN neurons (in some populations of CRF-immunoreactive neurons, among others) and that dopamine D1-like receptors are involved in the above effects. Finally, it is proposed that the long-lasting expression as well as the accumulation of DeltaFosB in the PVN may constitute a molecular basis underlying adaptive changes occurring in the HPA axis after relatively high doses of cocaine." @default.
• W2007859115 created "2016-06-24" @default.
• W2007859115 creator A5033225935 @default.
• W2007859115 creator A5058636204 @default.
• W2007859115 creator A5063666331 @default.
• W2007859115 date "2006-05-01" @default.
• W2007859115 modified "2023-10-16" @default.
• W2007859115 title "Acute and repeated cocaine induces alterations in FosB/ΔFosB expression in the paraventricular nucleus of the hypothalamus" @default.
• W2007859115 cites W1573648604 @default.
• W2007859115 cites W1600361555 @default.
• W2007859115 cites W1907295447 @default.
• W2007859115 cites W1964374986 @default.
• W2007859115 cites W1965290871 @default.
• W2007859115 cites W1966708273 @default.
• W2007859115 cites W1967616722 @default.
• W2007859115 cites W1971492732 @default.
• W2007859115 cites W1975620700 @default.
• W2007859115 cites W1979958212 @default.
• W2007859115 cites W1984346427 @default.
• W2007859115 cites W1984414190 @default.
• W2007859115 cites W1985371278 @default.
• W2007859115 cites W1987303311 @default.
• W2007859115 cites W1987765270 @default.
• W2007859115 cites W1989416066 @default.
• W2007859115 cites W1992427484 @default.
• W2007859115 cites W1995248567 @default.
• W2007859115 cites W2000696407 @default.
• W2007859115 cites W2006788291 @default.
• W2007859115 cites W2013405809 @default.
• W2007859115 cites W2016200185 @default.
• W2007859115 cites W2019223615 @default.
• W2007859115 cites W2021498374 @default.
• W2007859115 cites W2023703027 @default.
• W2007859115 cites W2028153921 @default.
• W2007859115 cites W2028466783 @default.
• W2007859115 cites W2028487839 @default.
• W2007859115 cites W2037155998 @default.
• W2007859115 cites W2037646583 @default.
• W2007859115 cites W2048606266 @default.
• W2007859115 cites W2051658894 @default.
• W2007859115 cites W2052288950 @default.
• W2007859115 cites W2057093585 @default.
• W2007859115 cites W2072157553 @default.
• W2007859115 cites W2075469347 @default.
• W2007859115 cites W2085049115 @default.
• W2007859115 cites W2093568105 @default.
• W2007859115 cites W2098121774 @default.
• W2007859115 cites W2102375624 @default.
• W2007859115 cites W2109518858 @default.
• W2007859115 cites W2126045393 @default.
• W2007859115 cites W2132750002 @default.
• W2007859115 cites W2143656230 @default.
• W2007859115 cites W2145708291 @default.
• W2007859115 cites W2166035496 @default.
• W2007859115 cites W2337823340 @default.
• W2007859115 cites W4292291195 @default.
• W2007859115 doi "https://doi.org/10.1016/j.brainres.2006.03.045" @default.
• W2007859115 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16674926" @default.
• W2007859115 hasPublicationYear "2006" @default.
• W2007859115 type Work @default.
• W2007859115 sameAs 2007859115 @default.
• W2007859115 citedByCount "25" @default.
• W2007859115 countsByYear W20078591152012 @default.
• W2007859115 countsByYear W20078591152013 @default.
• W2007859115 countsByYear W20078591152014 @default.
• W2007859115 countsByYear W20078591152015 @default.
• W2007859115 countsByYear W20078591152017 @default.
• W2007859115 countsByYear W20078591152021 @default.
• W2007859115 countsByYear W20078591152022 @default.
• W2007859115 crossrefType "journal-article" @default.
• W2007859115 hasAuthorship W2007859115A5033225935 @default.
• W2007859115 hasAuthorship W2007859115A5058636204 @default.
• W2007859115 hasAuthorship W2007859115A5063666331 @default.
• W2007859115 hasConcept C104317684 @default.
• W2007859115 hasConcept C126322002 @default.
• W2007859115 hasConcept C134018914 @default.
• W2007859115 hasConcept C150194340 @default.
• W2007859115 hasConcept C170493617 @default.
• W2007859115 hasConcept C185592680 @default.
• W2007859115 hasConcept C2776885963 @default.
• W2007859115 hasConcept C2777003273 @default.
• W2007859115 hasConcept C2777099045 @default.
• W2007859115 hasConcept C2780323455 @default.
• W2007859115 hasConcept C513476851 @default.
• W2007859115 hasConcept C54355233 @default.
• W2007859115 hasConcept C71924100 @default.
• W2007859115 hasConcept C86803240 @default.
• W2007859115 hasConceptScore W2007859115C104317684 @default.
• W2007859115 hasConceptScore W2007859115C126322002 @default.
• W2007859115 hasConceptScore W2007859115C134018914 @default.
• W2007859115 hasConceptScore W2007859115C150194340 @default.
• W2007859115 hasConceptScore W2007859115C170493617 @default.
• W2007859115 hasConceptScore W2007859115C185592680 @default.
• W2007859115 hasConceptScore W2007859115C2776885963 @default.
• W2007859115 hasConceptScore W2007859115C2777003273 @default.
• W2007859115 hasConceptScore W2007859115C2777099045 @default.
• W2007859115 hasConceptScore W2007859115C2780323455 @default.
• W2007859115 hasConceptScore W2007859115C513476851 @default.

• next