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- W2007859984 abstract "A recurrent theme of recent years has been the similarity between the molecular mechanisms that control pattern formation in vertebrates and invertebrates. While in some cases the same regulatory proteins and pathways carry out divergent functions in different organisms, the new data illuminate an outstanding example of a conserved ligand–receptor system operating with little apparent redundancy at the body midline. They also show how the individual experimental advantages of worms, flies and vertebrates can be put to good effect. Many interesting questions are raised, for example whether DCC-like proteins constitute a complete receptor system or an essential ligand-binding component, the relation between UNC-40 and UNC-5 in mediating repulsion, the existence of fly and vertebrate homologs of UNC-5, and the molecular pathways downstream of netrin reception. Given the conservation of the biology, it will be surprising if the regulatory events connected with netrins and their receptors are not also retained from nematodes to chordates." @default.
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- W2007859984 title "Axons Turn as Netrins Find Their Receptor" @default.
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- W2007859984 doi "https://doi.org/10.1016/s0896-6273(00)80235-4" @default.
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