FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007860377> ?p ?o ?g. }

• W2007860377 endingPage "3408" @default.
• W2007860377 startingPage "3398" @default.
• W2007860377 abstract "Striatal dopamine (DA) and acetylcholine (ACh) regulate motivated behaviors and striatal plasticity. Interactions between these neurotransmitters may be important, through synchronous changes in parent neuron activities and reciprocal presynaptic regulation of release. How DA signaling is regulated by striatal muscarinic receptors (mAChRs) is unresolved; contradictory reports indicate suppression or facilitation, implicating several mAChR subtypes on various neurons. We investigated whether mAChR regulation of DA signaling varies with presynaptic activity and identified the mAChRs responsible in sensorimotor- versus limbic-associated striatum. We detected DA in real time at carbon fiber microelectrodes in mouse striatal slices. Broad-spectrum mAChR agonists [oxotremorine-M, APET (arecaidine propargyl ester tosylate)] decreased DA release evoked by low-frequency stimuli (1–10 Hz, four pulses) but increased the sensitivity of DA release to presynaptic activity, even enhancing release by high frequencies (e.g., >25 Hz for four pulses). These bidirectional effects depended on ACh input to striatal nicotinic receptors (nAChRs) on DA axons but not GABA or glutamate input. In caudate–putamen (CPu), knock-out of M 2 - or M 4 -mAChRs (not M 5 ) prevented mAChR control of DA, indicating that M 2 - and M 4 -mAChRs are required. In nucleus accumbens (NAc) core or shell, mAChR function was prevented in M 4 -knock-outs, but not M 2 - or M 5 -knock-outs. These data indicate that striatal mAChRs, by inhibiting ACh release from cholinergic interneurons and thus modifying nAChR activity, offer variable control of DA release probability that promotes how DA release reflects activation of dopaminergic axons. Furthermore, different coupling of striatal M 2 /M 4 -mAChRs to the control of DA release in CPu versus NAc suggests targets to influence DA/ACh function differentially between striatal domains." @default.
• W2007860377 created "2016-06-24" @default.
• W2007860377 creator A5004604687 @default.
• W2007860377 creator A5015095365 @default.
• W2007860377 creator A5023730962 @default.
• W2007860377 creator A5030245353 @default.
• W2007860377 creator A5071588962 @default.
• W2007860377 creator A5087084011 @default.
• W2007860377 creator A5088856956 @default.
• W2007860377 date "2010-03-03" @default.
• W2007860377 modified "2023-09-30" @default.
• W2007860377 title "Striatal Muscarinic Receptors Promote Activity Dependence of Dopamine Transmission via Distinct Receptor Subtypes on Cholinergic Interneurons in Ventral versus Dorsal Striatum" @default.
• W2007860377 cites W1488744722 @default.
• W2007860377 cites W1494737704 @default.
• W2007860377 cites W1518922051 @default.
• W2007860377 cites W1519949248 @default.
• W2007860377 cites W1543271211 @default.
• W2007860377 cites W1551771994 @default.
• W2007860377 cites W1557320868 @default.
• W2007860377 cites W1557961794 @default.
• W2007860377 cites W1598962518 @default.
• W2007860377 cites W1736742270 @default.
• W2007860377 cites W1776364276 @default.
• W2007860377 cites W1798722234 @default.
• W2007860377 cites W1803352854 @default.
• W2007860377 cites W1831076810 @default.
• W2007860377 cites W1871288096 @default.
• W2007860377 cites W1874938414 @default.
• W2007860377 cites W1882858722 @default.
• W2007860377 cites W1885050361 @default.
• W2007860377 cites W1901778362 @default.
• W2007860377 cites W1964499248 @default.
• W2007860377 cites W1976396271 @default.
• W2007860377 cites W1977353877 @default.
• W2007860377 cites W1978932203 @default.
• W2007860377 cites W1979002023 @default.
• W2007860377 cites W1979197925 @default.
• W2007860377 cites W1980540768 @default.
• W2007860377 cites W1985890505 @default.
• W2007860377 cites W1995931442 @default.
• W2007860377 cites W1998152406 @default.
• W2007860377 cites W1998777125 @default.
• W2007860377 cites W1998995979 @default.
• W2007860377 cites W1999198024 @default.
• W2007860377 cites W1999774383 @default.
• W2007860377 cites W2007480720 @default.
• W2007860377 cites W2007836474 @default.
• W2007860377 cites W2023374499 @default.
• W2007860377 cites W2023455262 @default.
• W2007860377 cites W2023796931 @default.
• W2007860377 cites W2025170140 @default.
• W2007860377 cites W2028725530 @default.
• W2007860377 cites W2035289099 @default.
• W2007860377 cites W2039654930 @default.
• W2007860377 cites W2043125642 @default.
• W2007860377 cites W2043496808 @default.
• W2007860377 cites W2068480458 @default.
• W2007860377 cites W2068538092 @default.
• W2007860377 cites W2071652879 @default.
• W2007860377 cites W2072308972 @default.
• W2007860377 cites W2075831689 @default.
• W2007860377 cites W2084304884 @default.
• W2007860377 cites W2085374324 @default.
• W2007860377 cites W2095088925 @default.
• W2007860377 cites W2096022141 @default.
• W2007860377 cites W2096830703 @default.
• W2007860377 cites W2108547360 @default.
• W2007860377 cites W2109059823 @default.
• W2007860377 cites W2109438739 @default.
• W2007860377 cites W2110405906 @default.
• W2007860377 cites W2112338700 @default.
• W2007860377 cites W2116626218 @default.
• W2007860377 cites W2120163774 @default.
• W2007860377 cites W2120804633 @default.
• W2007860377 cites W2136267239 @default.
• W2007860377 cites W2144534164 @default.
• W2007860377 cites W2147183145 @default.
• W2007860377 cites W2148134595 @default.
• W2007860377 cites W2154145851 @default.
• W2007860377 cites W2155036206 @default.
• W2007860377 cites W2157984060 @default.
• W2007860377 cites W2160963011 @default.
• W2007860377 cites W2160999761 @default.
• W2007860377 cites W2162288656 @default.
• W2007860377 cites W2168503470 @default.
• W2007860377 cites W2171281715 @default.
• W2007860377 cites W4297820098 @default.
• W2007860377 doi "https://doi.org/10.1523/jneurosci.5620-09.2010" @default.
• W2007860377 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2866006" @default.
• W2007860377 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20203199" @default.
• W2007860377 hasPublicationYear "2010" @default.
• W2007860377 type Work @default.
• W2007860377 sameAs 2007860377 @default.
• W2007860377 citedByCount "166" @default.
• W2007860377 countsByYear W20078603772012 @default.
• W2007860377 countsByYear W20078603772013 @default.
• W2007860377 countsByYear W20078603772014 @default.
• W2007860377 countsByYear W20078603772015 @default.

• next