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- W2007862015 abstract "Red cells and the lens of the eye are non-nucleated cells; moreover, they have metabolic similarities. Cataracts develop in childhood in homozygotes for galactosaemic abnormalities, which can be detected by biochemical measurements in red blood-cells. It has not been determined whether heterozygotes for these defects are at greater risk for cataract development later in life. Similarly, riboflavin deficiecy for which the erythrocyte is a sensitive indicator, has been associated with cataracts in animals. Red-cell studies were carried out in 22 patients, aged under 50, with cataracts. Heterozygosity for galactokinase deficiency was detected in 5 patients, for galactose-uridyl transferase in 2, and evidence of an erythrocytic deficiency of riboflavin in 8. Even when Black subjects were excluded from analysis because of their high incidence of polymorphism for galactokinase, these findings are significantly different from those expected from population surveys and suggest that many patients with presenile cataracts have a biochemical abnormality which can be detected by examination of red blood-cells and which may be corrected by dietary restrictions or supplements." @default.
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- W2007862015 date "1978-01-01" @default.
- W2007862015 modified "2023-10-05" @default.
- W2007862015 title "ASSOCIATION OF PRESENILE CATARACTS WITH HETEROZYGOSITY FOR GALACTOSÆMIC STATES AND WITH RIBOFLAVIN DEFICIENCY" @default.
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- W2007862015 doi "https://doi.org/10.1016/s0140-6736(78)90359-8" @default.
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