FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007863359> ?p ?o ?g. }

• W2007863359 endingPage "338" @default.
• W2007863359 startingPage "331" @default.
• W2007863359 abstract "Summary Pm-VEGF, a novel member ofVEGF family from the venom gland of Taiwan habu (Protobothrops mucrosquamatu), is a disulfidelinked homodimer with 119 amino acid residues. Recombinant fusion Pm-VEGF was expressed in Escherichia coli, purified and refolded. Surface plasmon resonance was used to determine its binding kinetics toVEGF-receptors (VEGFR). Relative to human VEGF165, the binding affinity of Pm-VEGF to the VEGFR-1 was 1.7-fold higher while affinity to the VEGFR-2 was 17-fold lower. But it did not bind theVEGFR-3 or neuropilin-1. Pm-VEGF promoted the proliferation and tissue factor production of endothelial cells, the neovascularization in the chicken chorioallantoic membrane, and increased vascular permeability. It also stimulated tissue-factor production and human monocyte chemotaxis, in accord with its specificity for VEGFR-1. Structural comparison among VEGF-proteins from various viper venoms revealed that the two subfamilies of vipers (Crotalinae and Viperinae) have evolved with distinct receptor-specificities for VEGFR-1 and VEGFR-2, respectively. Discussion on structureactivity relationships of the VEGFs further provided insight into residues important for the receptor-binding and specificities." @default.
• W2007863359 created "2016-06-24" @default.
• W2007863359 creator A5017817869 @default.
• W2007863359 creator A5022237359 @default.
• W2007863359 creator A5027620511 @default.
• W2007863359 creator A5066084120 @default.
• W2007863359 date "2005-01-01" @default.
• W2007863359 modified "2023-09-29" @default.
• W2007863359 title "Crotalid venom vascular endothelial growth factors has preferential affinity for VEGFR-1" @default.
• W2007863359 cites W1489873347 @default.
• W2007863359 cites W1587020653 @default.
• W2007863359 cites W1600542667 @default.
• W2007863359 cites W1624346216 @default.
• W2007863359 cites W1891984009 @default.
• W2007863359 cites W1963876488 @default.
• W2007863359 cites W1965380392 @default.
• W2007863359 cites W1975535670 @default.
• W2007863359 cites W1981612052 @default.
• W2007863359 cites W1985712533 @default.
• W2007863359 cites W1986024946 @default.
• W2007863359 cites W1986559037 @default.
• W2007863359 cites W1993473599 @default.
• W2007863359 cites W1999550517 @default.
• W2007863359 cites W2000292756 @default.
• W2007863359 cites W2002049222 @default.
• W2007863359 cites W2004907588 @default.
• W2007863359 cites W2005342420 @default.
• W2007863359 cites W2009408493 @default.
• W2007863359 cites W2010947174 @default.
• W2007863359 cites W2013561902 @default.
• W2007863359 cites W2017205210 @default.
• W2007863359 cites W2032882287 @default.
• W2007863359 cites W2037211988 @default.
• W2007863359 cites W2046516822 @default.
• W2007863359 cites W2050252862 @default.
• W2007863359 cites W2051268134 @default.
• W2007863359 cites W2053286622 @default.
• W2007863359 cites W2055417351 @default.
• W2007863359 cites W2066770029 @default.
• W2007863359 cites W2084506573 @default.
• W2007863359 cites W2094368534 @default.
• W2007863359 cites W2095850556 @default.
• W2007863359 cites W2106882534 @default.
• W2007863359 cites W2116730805 @default.
• W2007863359 cites W2121594719 @default.
• W2007863359 cites W2130361087 @default.
• W2007863359 cites W2141046053 @default.
• W2007863359 cites W2146953551 @default.
• W2007863359 cites W2158316748 @default.
• W2007863359 cites W2166156136 @default.
• W2007863359 cites W2166528783 @default.
• W2007863359 cites W426067948 @default.
• W2007863359 doi "https://doi.org/10.1160/th04-09-0568" @default.
• W2007863359 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15711751" @default.
• W2007863359 hasPublicationYear "2005" @default.
• W2007863359 type Work @default.
• W2007863359 sameAs 2007863359 @default.
• W2007863359 citedByCount "17" @default.
• W2007863359 countsByYear W20078633592013 @default.
• W2007863359 countsByYear W20078633592014 @default.
• W2007863359 countsByYear W20078633592015 @default.
• W2007863359 countsByYear W20078633592017 @default.
• W2007863359 countsByYear W20078633592021 @default.
• W2007863359 countsByYear W20078633592022 @default.
• W2007863359 countsByYear W20078633592023 @default.
• W2007863359 crossrefType "journal-article" @default.
• W2007863359 hasAuthorship W2007863359A5017817869 @default.
• W2007863359 hasAuthorship W2007863359A5022237359 @default.
• W2007863359 hasAuthorship W2007863359A5027620511 @default.
• W2007863359 hasAuthorship W2007863359A5066084120 @default.
• W2007863359 hasConcept C104317684 @default.
• W2007863359 hasConcept C113045295 @default.
• W2007863359 hasConcept C134018914 @default.
• W2007863359 hasConcept C146285616 @default.
• W2007863359 hasConcept C14858245 @default.
• W2007863359 hasConcept C153911025 @default.
• W2007863359 hasConcept C167734588 @default.
• W2007863359 hasConcept C170493617 @default.
• W2007863359 hasConcept C2777025900 @default.
• W2007863359 hasConcept C2779448229 @default.
• W2007863359 hasConcept C2780394083 @default.
• W2007863359 hasConcept C40767141 @default.
• W2007863359 hasConcept C502942594 @default.
• W2007863359 hasConcept C55493867 @default.
• W2007863359 hasConcept C86803240 @default.
• W2007863359 hasConcept C95444343 @default.
• W2007863359 hasConcept C97230052 @default.
• W2007863359 hasConceptScore W2007863359C104317684 @default.
• W2007863359 hasConceptScore W2007863359C113045295 @default.
• W2007863359 hasConceptScore W2007863359C134018914 @default.
• W2007863359 hasConceptScore W2007863359C146285616 @default.
• W2007863359 hasConceptScore W2007863359C14858245 @default.
• W2007863359 hasConceptScore W2007863359C153911025 @default.
• W2007863359 hasConceptScore W2007863359C167734588 @default.
• W2007863359 hasConceptScore W2007863359C170493617 @default.
• W2007863359 hasConceptScore W2007863359C2777025900 @default.
• W2007863359 hasConceptScore W2007863359C2779448229 @default.
• W2007863359 hasConceptScore W2007863359C2780394083 @default.

• next