Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007868087> ?p ?o ?g. }
- W2007868087 endingPage "364" @default.
- W2007868087 startingPage "352" @default.
- W2007868087 abstract "Binding of High Density Lipoprotein (HDL) and its major apolipoprotein A-I (apoA-I) to cell surface receptors is believed to initiate a plethora of signaling cascades that promote atheroprotective cell behavior, including the removal of excess cholesterol from lipid-loaded macrophages. More specifically, HDL and apoA-I binding to scavenger receptor BI (SR-BI) and ATP-binding cassette (ABC) transporter A1 has been shown to activate protein kinase A and C (PKA, PKC), Rac/Rho GTPases, Janus Kinase 2 (JAK2), calmodulin as well as mitogen-activated protein kinases (MAPK). Some of these signaling events upregulate mobilization of cholesterol from cellular pools, while others promote efflux pathways through increased expression, stability, and cell surface localization of SR-BI and ABCA1. This review aims to summarize the current knowledge of HDL- and apoA-I -induced signal transduction pathways that are linked to cholesterol efflux and discusses the underlying mechanisms that could couple ligand binding to SR-BI and ABCA1 with signaling and cholesterol export. Additional focus is given on the potential of pharmacological intervention to modulate the activity of signaling cascades for the inhibition or regression of cholesterol accumulation in atherosclerotic lesions." @default.
- W2007868087 created "2016-06-24" @default.
- W2007868087 creator A5002868089 @default.
- W2007868087 creator A5006988155 @default.
- W2007868087 creator A5027752685 @default.
- W2007868087 creator A5042164155 @default.
- W2007868087 creator A5071105199 @default.
- W2007868087 date "2012-02-01" @default.
- W2007868087 modified "2023-09-24" @default.
- W2007868087 title "Signal Transduction Pathways Provide Opportunities to Enhance HDL and apoAI-Dependent Reverse Cholesterol Transport" @default.
- W2007868087 cites W1498171831 @default.
- W2007868087 cites W1499822666 @default.
- W2007868087 cites W1505364624 @default.
- W2007868087 cites W1539163551 @default.
- W2007868087 cites W1564861448 @default.
- W2007868087 cites W1964094832 @default.
- W2007868087 cites W1967600226 @default.
- W2007868087 cites W1968228298 @default.
- W2007868087 cites W1969110010 @default.
- W2007868087 cites W1969232152 @default.
- W2007868087 cites W1969250188 @default.
- W2007868087 cites W1973195548 @default.
- W2007868087 cites W1974864595 @default.
- W2007868087 cites W1978488816 @default.
- W2007868087 cites W1980352486 @default.
- W2007868087 cites W1980814667 @default.
- W2007868087 cites W1982283178 @default.
- W2007868087 cites W1983048699 @default.
- W2007868087 cites W1983681727 @default.
- W2007868087 cites W1985170971 @default.
- W2007868087 cites W1985415000 @default.
- W2007868087 cites W1986214532 @default.
- W2007868087 cites W1989061296 @default.
- W2007868087 cites W1989188411 @default.
- W2007868087 cites W1996830657 @default.
- W2007868087 cites W1996895583 @default.
- W2007868087 cites W1998349282 @default.
- W2007868087 cites W1998624303 @default.
- W2007868087 cites W2002530279 @default.
- W2007868087 cites W2006295614 @default.
- W2007868087 cites W2009832539 @default.
- W2007868087 cites W2011123221 @default.
- W2007868087 cites W2012647353 @default.
- W2007868087 cites W2012786952 @default.
- W2007868087 cites W2014644214 @default.
- W2007868087 cites W2014783744 @default.
- W2007868087 cites W2015119995 @default.
- W2007868087 cites W2016399150 @default.
- W2007868087 cites W2017670475 @default.
- W2007868087 cites W2018285329 @default.
- W2007868087 cites W2021796556 @default.
- W2007868087 cites W2024692118 @default.
- W2007868087 cites W2028858008 @default.
- W2007868087 cites W2031722933 @default.
- W2007868087 cites W2033554531 @default.
- W2007868087 cites W2033839892 @default.
- W2007868087 cites W2037083050 @default.
- W2007868087 cites W2037678728 @default.
- W2007868087 cites W2039339432 @default.
- W2007868087 cites W2041298355 @default.
- W2007868087 cites W2043461724 @default.
- W2007868087 cites W2043494958 @default.
- W2007868087 cites W2044906986 @default.
- W2007868087 cites W2045521563 @default.
- W2007868087 cites W2048489471 @default.
- W2007868087 cites W2052931002 @default.
- W2007868087 cites W2053100392 @default.
- W2007868087 cites W2053133567 @default.
- W2007868087 cites W2053365325 @default.
- W2007868087 cites W2055660210 @default.
- W2007868087 cites W2055916074 @default.
- W2007868087 cites W2056486103 @default.
- W2007868087 cites W2056487627 @default.
- W2007868087 cites W2057847302 @default.
- W2007868087 cites W2058196012 @default.
- W2007868087 cites W2058205407 @default.
- W2007868087 cites W2059612359 @default.
- W2007868087 cites W2060747458 @default.
- W2007868087 cites W2062030534 @default.
- W2007868087 cites W2064911233 @default.
- W2007868087 cites W2065281265 @default.
- W2007868087 cites W2065617298 @default.
- W2007868087 cites W2069160356 @default.
- W2007868087 cites W2070275599 @default.
- W2007868087 cites W2073394241 @default.
- W2007868087 cites W2073446479 @default.
- W2007868087 cites W2073996882 @default.
- W2007868087 cites W2076490603 @default.
- W2007868087 cites W2077483459 @default.
- W2007868087 cites W2081478756 @default.
- W2007868087 cites W2083019830 @default.
- W2007868087 cites W2083254362 @default.
- W2007868087 cites W2084072781 @default.
- W2007868087 cites W2084074011 @default.
- W2007868087 cites W2085656832 @default.
- W2007868087 cites W2089734476 @default.
- W2007868087 cites W2090711903 @default.
- W2007868087 cites W2091530001 @default.