FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007873035> ?p ?o ?g. }

• W2007873035 endingPage "2671" @default.
• W2007873035 startingPage "2656" @default.
• W2007873035 abstract "This paper presents the first unified quantitative study of the effects of butyrate concentration upon (1) cell-cycle progression, (2) modification of all inner histones, (3) dephosphorylation of histone H1, and (4) enhancement of an H1-like protein (BEP) in CHO cells. Flow cytometric analysis shows that exposure to butyrate enriches CHO cultures in G1 cells and, at sufficient butyrate concentration, leads to G1 arrest. Additionally, butyrate alters the rate of cell-cycle progression through G2/M and through S. Two-dimensional polyacrylamide electrophoresis and radiolabeling in butyrate-treated cultures indicate the presence of at least one site of internal acetylation in histone H2A, four sites of internal acetylation in histone H2B, five sites of internal acetylation in histone H3, and four sites of internal acetylation in histone H4. Histone H2A is also appreciably phosphorylated, so that it is acetylated and phosphorylated at a total of up to three sites. The distribution of modified species for all the inner (core) histones has been quantified from two-dimensional gels by using the three different methods of analysis? (1) direct densitometry of excised portions of the gel, (2) scintillation spectrometry of 3H-labeled histones, and (3) microdensitometry of photographic negatives. At 15 mM butyrate, 26% of H2B is acetylated at three to four sites, 37% of H3 is acetylated at three to five sites, and 50% of H4 is acetylated at three to four sites. Histone H1 is dephosphorylated as a function of butyrate concentration, and the dephosphorylation can be correlated with an increased proportion of G1 cells in culture. There is also a significant increase in the cellular content of two other proteins when cells are exposed to butyrate. The increase in one of these, BEP, has been quantified as a function of butyrate concentration after 24 h of exposure to butyrate. BEP appears to be related to histone H1O [Panyim, S., & Chalkley, R. (1969) Biochem. Biophys. Res. Commun. 37, 1042] and to induced protein IP25 [Keppel, F., Allet, B., & Eisen, H. (1977) Proc. Natl. Acad. Sci. U.S.A. 74, 653]. The other protein (UP), which has a molecular weight of approximately 15 000, has not been identified. Butyrate induces a twofold increase in the cellular content of UP and a change in the distribution of UP molecular species." @default.
• W2007873035 created "2016-06-24" @default.
• W2007873035 creator A5078937757 @default.
• W2007873035 creator A5086712795 @default.
• W2007873035 creator A5091484920 @default.
• W2007873035 date "1980-06-10" @default.
• W2007873035 modified "2023-10-17" @default.
• W2007873035 title "Concentration-dependent effects of sodium butyrate in Chinese hamster cells: cell-cycle progression, inner-histone acetylation, histone H1 dephosphorylation, and induction of an H1-like protein" @default.
• W2007873035 cites W138633729 @default.
• W2007873035 cites W1482723536 @default.
• W2007873035 cites W1515078836 @default.
• W2007873035 cites W1535941896 @default.
• W2007873035 cites W1547908140 @default.
• W2007873035 cites W1549004484 @default.
• W2007873035 cites W1555044868 @default.
• W2007873035 cites W1570759257 @default.
• W2007873035 cites W1574385690 @default.
• W2007873035 cites W1601679319 @default.
• W2007873035 cites W1601712430 @default.
• W2007873035 cites W1606423922 @default.
• W2007873035 cites W1607738859 @default.
• W2007873035 cites W1946094435 @default.
• W2007873035 cites W1963507142 @default.
• W2007873035 cites W1965219854 @default.
• W2007873035 cites W1969426009 @default.
• W2007873035 cites W1974313609 @default.
• W2007873035 cites W1979935703 @default.
• W2007873035 cites W1985527733 @default.
• W2007873035 cites W1988207539 @default.
• W2007873035 cites W1990984094 @default.
• W2007873035 cites W1996266432 @default.
• W2007873035 cites W1998006710 @default.
• W2007873035 cites W2000277663 @default.
• W2007873035 cites W2001373008 @default.
• W2007873035 cites W2001618000 @default.
• W2007873035 cites W2002640221 @default.
• W2007873035 cites W2003082497 @default.
• W2007873035 cites W2004181810 @default.
• W2007873035 cites W2004360936 @default.
• W2007873035 cites W2011783533 @default.
• W2007873035 cites W2014828652 @default.
• W2007873035 cites W2022415916 @default.
• W2007873035 cites W2028938083 @default.
• W2007873035 cites W2031236107 @default.
• W2007873035 cites W2035692772 @default.
• W2007873035 cites W2036027789 @default.
• W2007873035 cites W2044007120 @default.
• W2007873035 cites W2045632769 @default.
• W2007873035 cites W2046571799 @default.
• W2007873035 cites W2048902078 @default.
• W2007873035 cites W2049349137 @default.
• W2007873035 cites W2049618391 @default.
• W2007873035 cites W2050036623 @default.
• W2007873035 cites W2051237347 @default.
• W2007873035 cites W2052254756 @default.
• W2007873035 cites W2057850047 @default.
• W2007873035 cites W2058017613 @default.
• W2007873035 cites W2059722081 @default.
• W2007873035 cites W2067839546 @default.
• W2007873035 cites W2068218406 @default.
• W2007873035 cites W2069469862 @default.
• W2007873035 cites W2072955812 @default.
• W2007873035 cites W2073452177 @default.
• W2007873035 cites W2073879684 @default.
• W2007873035 cites W2083085787 @default.
• W2007873035 cites W2083489369 @default.
• W2007873035 cites W2084324725 @default.
• W2007873035 cites W2086123963 @default.
• W2007873035 cites W2092362325 @default.
• W2007873035 cites W2100805638 @default.
• W2007873035 cites W2100837269 @default.
• W2007873035 cites W2107270084 @default.
• W2007873035 cites W2115659567 @default.
• W2007873035 cites W2135446927 @default.
• W2007873035 cites W2141623679 @default.
• W2007873035 cites W2143224884 @default.
• W2007873035 cites W2148928117 @default.
• W2007873035 cites W2161829332 @default.
• W2007873035 cites W2167988586 @default.
• W2007873035 cites W2176858216 @default.
• W2007873035 cites W2234778117 @default.
• W2007873035 cites W2277383493 @default.
• W2007873035 cites W2316838174 @default.
• W2007873035 cites W2322149866 @default.
• W2007873035 cites W2917909130 @default.
• W2007873035 cites W70507114 @default.
• W2007873035 doi "https://doi.org/10.1021/bi00553a019" @default.
• W2007873035 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7397096" @default.
• W2007873035 hasPublicationYear "1980" @default.
• W2007873035 type Work @default.
• W2007873035 sameAs 2007873035 @default.
• W2007873035 citedByCount "194" @default.
• W2007873035 countsByYear W20078730352018 @default.
• W2007873035 countsByYear W20078730352020 @default.
• W2007873035 countsByYear W20078730352021 @default.
• W2007873035 countsByYear W20078730352022 @default.
• W2007873035 countsByYear W20078730352023 @default.
• W2007873035 crossrefType "journal-article" @default.

• next