Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007880010> ?p ?o ?g. }
- W2007880010 endingPage "118" @default.
- W2007880010 startingPage "108" @default.
- W2007880010 abstract "Major depressive disorder (MDD) is predicted to be the second leading cause of disability worldwide by the year 2020. Currently available treatments for MDD are suboptimal. Only 50% of MDD patients recover in less than 12 weeks with adequate treatment, and up to 20% of patients will fail to adequately respond to all currently available interventions. Moreover, current treatments come at the cost of significant central nervous system (CNS) side effects, further highlighting the need for more effective treatments with fewer side effects. A greater mechanistic understanding of MDD and the actions of antidepressant drugs would provide opportunities for development of novel therapeutic approaches to treatment. With this aim in mind, we explore the novel, but empirically supported, hypothesis that an evolutionarily ancient thermoafferent pathway, signaling via the spinoparabrachial pathway from serotonergic sensory cells in the skin and other epithelial linings to serotonergic neurons and depression-related circuits in the brain, is dysfunctional in MDD and that antidepressant therapies, including antidepressant drugs and exercise, act by restoring its function." @default.
- W2007880010 created "2016-06-24" @default.
- W2007880010 creator A5020963967 @default.
- W2007880010 creator A5024726266 @default.
- W2007880010 creator A5088302314 @default.
- W2007880010 date "2013-01-01" @default.
- W2007880010 modified "2023-09-27" @default.
- W2007880010 title "Integrative physiology of depression and antidepressant drug action: Implications for serotonergic mechanisms of action and novel therapeutic strategies for treatment of depression" @default.
- W2007880010 cites W111841309 @default.
- W2007880010 cites W1485369766 @default.
- W2007880010 cites W1562660682 @default.
- W2007880010 cites W1590155247 @default.
- W2007880010 cites W1828538530 @default.
- W2007880010 cites W1929691281 @default.
- W2007880010 cites W1964403908 @default.
- W2007880010 cites W1967075670 @default.
- W2007880010 cites W1969776301 @default.
- W2007880010 cites W1972383405 @default.
- W2007880010 cites W1974334176 @default.
- W2007880010 cites W1975355521 @default.
- W2007880010 cites W1976114760 @default.
- W2007880010 cites W1976588989 @default.
- W2007880010 cites W1976619257 @default.
- W2007880010 cites W1977160269 @default.
- W2007880010 cites W1977805523 @default.
- W2007880010 cites W1979306029 @default.
- W2007880010 cites W1979410529 @default.
- W2007880010 cites W1980168859 @default.
- W2007880010 cites W1980616363 @default.
- W2007880010 cites W1981454105 @default.
- W2007880010 cites W1985623264 @default.
- W2007880010 cites W1989452485 @default.
- W2007880010 cites W1993320854 @default.
- W2007880010 cites W1995226460 @default.
- W2007880010 cites W1999165328 @default.
- W2007880010 cites W1999616055 @default.
- W2007880010 cites W2000255674 @default.
- W2007880010 cites W2000659468 @default.
- W2007880010 cites W2001525384 @default.
- W2007880010 cites W2003455153 @default.
- W2007880010 cites W2003508747 @default.
- W2007880010 cites W2003586939 @default.
- W2007880010 cites W2007003996 @default.
- W2007880010 cites W2007682013 @default.
- W2007880010 cites W2007702924 @default.
- W2007880010 cites W2009485991 @default.
- W2007880010 cites W2009500086 @default.
- W2007880010 cites W2010269783 @default.
- W2007880010 cites W2010500545 @default.
- W2007880010 cites W2011003051 @default.
- W2007880010 cites W2011403542 @default.
- W2007880010 cites W2011973103 @default.
- W2007880010 cites W2012543343 @default.
- W2007880010 cites W2013373554 @default.
- W2007880010 cites W2014213308 @default.
- W2007880010 cites W2015780545 @default.
- W2007880010 cites W2016146445 @default.
- W2007880010 cites W2016336988 @default.
- W2007880010 cites W2019110477 @default.
- W2007880010 cites W2024666180 @default.
- W2007880010 cites W2024803642 @default.
- W2007880010 cites W2025704372 @default.
- W2007880010 cites W2027701529 @default.
- W2007880010 cites W2028054765 @default.
- W2007880010 cites W2028711976 @default.
- W2007880010 cites W2028890830 @default.
- W2007880010 cites W2029766082 @default.
- W2007880010 cites W2030946465 @default.
- W2007880010 cites W2031347742 @default.
- W2007880010 cites W2031639949 @default.
- W2007880010 cites W2033432219 @default.
- W2007880010 cites W2035961560 @default.
- W2007880010 cites W2036744872 @default.
- W2007880010 cites W2037650611 @default.
- W2007880010 cites W2039409559 @default.
- W2007880010 cites W2039502108 @default.
- W2007880010 cites W2041217302 @default.
- W2007880010 cites W2042198171 @default.
- W2007880010 cites W2045135465 @default.
- W2007880010 cites W2045290451 @default.
- W2007880010 cites W2045943472 @default.
- W2007880010 cites W2046186483 @default.
- W2007880010 cites W2046333388 @default.
- W2007880010 cites W2046829371 @default.
- W2007880010 cites W2047033000 @default.
- W2007880010 cites W2048881476 @default.
- W2007880010 cites W2049363804 @default.
- W2007880010 cites W2050690304 @default.
- W2007880010 cites W2050716480 @default.
- W2007880010 cites W2051919258 @default.
- W2007880010 cites W2053720210 @default.
- W2007880010 cites W2055799029 @default.
- W2007880010 cites W2056575770 @default.
- W2007880010 cites W2056706443 @default.
- W2007880010 cites W2057378152 @default.
- W2007880010 cites W2058877872 @default.
- W2007880010 cites W2060334672 @default.
- W2007880010 cites W2060359473 @default.