FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007880140> ?p ?o ?g. }

• W2007880140 endingPage "535" @default.
• W2007880140 startingPage "525" @default.
• W2007880140 abstract "Squamous cell carcinoma of the head and neck (SCCHN) cells can escape recognition by tumor antigen (TA)-specific cytotoxic T lymphocytes (CTL) by downregulation of antigen processing machinery (APM) components, such as the transporter associated with antigen processing (TAP)-1/2 heterodimer. APM component upregulation by interferon gamma (IFN-γ) restores SCCHN cell recognition and susceptibility to lysis by CTL, but the mechanism underlying TAP1/2 downregulation in SCCHN cells is not known. Because IFN-γ activates signal transducer and activator of transcription (STAT)-1, we investigated phosphorylated (p)-STAT1 as a mediator of low basal TAP1/2 expression in SCCHN cells. SCCHN cells were found to express basal total STAT1 but low to undetectable levels of activated STAT1. The association of increased pSTAT1 levels and APM components likely reflects a cause–effect relationship, since STAT1 knockdown significantly reduced both IFN-γ-mediated APM component expression and TA-specific CTL recognition of IFN-γ-treated SCCHN cells. On the other hand, since oncogenic pSTAT3 is overexpressed in SCCHN cells and was found to heterodimerize with pSTAT1, we also tested whether pSTAT3 and pSTAT1:pSTAT3 heterodimers inhibited IFN-γ-induced STAT1 activation and APM component expression. First, STAT3 activation or depletion did not affect basal or IFN-γ-induced expression of pSTAT1 and APM components or recognition of SCCHN cells by TA-specific CTL. Second, pSTAT1:pSTAT3 heterodimers did not interfere with IFN-γ-induced STAT1 binding to the TAP1 promoter or APM protein expression. These findings demonstrate that APM component downregulation is regulated primarily by an IFN-γ-pSTAT1-mediated signaling pathway, independent of oncogenic STAT3 overexpression in SCCHN cells." @default.
• W2007880140 created "2016-06-24" @default.
• W2007880140 creator A5028669896 @default.
• W2007880140 creator A5055366752 @default.
• W2007880140 creator A5083740731 @default.
• W2007880140 creator A5086074491 @default.
• W2007880140 date "2011-01-05" @default.
• W2007880140 modified "2023-10-03" @default.
• W2007880140 title "Deficiency of activated STAT1 in head and neck cancer cells mediates TAP1-dependent escape from cytotoxic T lymphocytes" @default.
• W2007880140 cites W1496671606 @default.
• W2007880140 cites W1549291581 @default.
• W2007880140 cites W1782561717 @default.
• W2007880140 cites W1892781835 @default.
• W2007880140 cites W1953731166 @default.
• W2007880140 cites W1965828942 @default.
• W2007880140 cites W1965882390 @default.
• W2007880140 cites W1973986761 @default.
• W2007880140 cites W1981799488 @default.
• W2007880140 cites W1982664065 @default.
• W2007880140 cites W1982981861 @default.
• W2007880140 cites W1983989619 @default.
• W2007880140 cites W1987752224 @default.
• W2007880140 cites W2001852133 @default.
• W2007880140 cites W2020634849 @default.
• W2007880140 cites W2021164055 @default.
• W2007880140 cites W2026841252 @default.
• W2007880140 cites W2027834847 @default.
• W2007880140 cites W2033326553 @default.
• W2007880140 cites W2041187882 @default.
• W2007880140 cites W2064488799 @default.
• W2007880140 cites W2068116723 @default.
• W2007880140 cites W2068430237 @default.
• W2007880140 cites W2075720041 @default.
• W2007880140 cites W2076106140 @default.
• W2007880140 cites W2084371366 @default.
• W2007880140 cites W2085384499 @default.
• W2007880140 cites W2091824579 @default.
• W2007880140 cites W2113640115 @default.
• W2007880140 cites W2138717155 @default.
• W2007880140 cites W2139994202 @default.
• W2007880140 cites W2146383480 @default.
• W2007880140 cites W2149252678 @default.
• W2007880140 cites W2154684298 @default.
• W2007880140 cites W2161424280 @default.
• W2007880140 cites W2316520276 @default.
• W2007880140 doi "https://doi.org/10.1007/s00262-010-0961-7" @default.
• W2007880140 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3426276" @default.
• W2007880140 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21207025" @default.
• W2007880140 hasPublicationYear "2011" @default.
• W2007880140 type Work @default.
• W2007880140 sameAs 2007880140 @default.
• W2007880140 citedByCount "84" @default.
• W2007880140 countsByYear W20078801402012 @default.
• W2007880140 countsByYear W20078801402013 @default.
• W2007880140 countsByYear W20078801402014 @default.
• W2007880140 countsByYear W20078801402015 @default.
• W2007880140 countsByYear W20078801402016 @default.
• W2007880140 countsByYear W20078801402017 @default.
• W2007880140 countsByYear W20078801402018 @default.
• W2007880140 countsByYear W20078801402019 @default.
• W2007880140 countsByYear W20078801402020 @default.
• W2007880140 countsByYear W20078801402021 @default.
• W2007880140 countsByYear W20078801402022 @default.
• W2007880140 countsByYear W20078801402023 @default.
• W2007880140 crossrefType "journal-article" @default.
• W2007880140 hasAuthorship W2007880140A5028669896 @default.
• W2007880140 hasAuthorship W2007880140A5055366752 @default.
• W2007880140 hasAuthorship W2007880140A5083740731 @default.
• W2007880140 hasAuthorship W2007880140A5086074491 @default.
• W2007880140 hasBestOaLocation W20078801402 @default.
• W2007880140 hasConcept C104317684 @default.
• W2007880140 hasConcept C127561419 @default.
• W2007880140 hasConcept C147483822 @default.
• W2007880140 hasConcept C147969180 @default.
• W2007880140 hasConcept C153911025 @default.
• W2007880140 hasConcept C154317977 @default.
• W2007880140 hasConcept C167672396 @default.
• W2007880140 hasConcept C171958077 @default.
• W2007880140 hasConcept C173396325 @default.
• W2007880140 hasConcept C190283241 @default.
• W2007880140 hasConcept C202751555 @default.
• W2007880140 hasConcept C203014093 @default.
• W2007880140 hasConcept C2776178377 @default.
• W2007880140 hasConcept C2777003663 @default.
• W2007880140 hasConcept C2778923194 @default.
• W2007880140 hasConcept C502942594 @default.
• W2007880140 hasConcept C55493867 @default.
• W2007880140 hasConcept C62478195 @default.
• W2007880140 hasConcept C86803240 @default.
• W2007880140 hasConcept C95444343 @default.
• W2007880140 hasConceptScore W2007880140C104317684 @default.
• W2007880140 hasConceptScore W2007880140C127561419 @default.
• W2007880140 hasConceptScore W2007880140C147483822 @default.
• W2007880140 hasConceptScore W2007880140C147969180 @default.
• W2007880140 hasConceptScore W2007880140C153911025 @default.
• W2007880140 hasConceptScore W2007880140C154317977 @default.
• W2007880140 hasConceptScore W2007880140C167672396 @default.
• W2007880140 hasConceptScore W2007880140C171958077 @default.

• next