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• W2007881209 endingPage "e1003366" @default.
• W2007881209 startingPage "e1003366" @default.
• W2007881209 abstract "Genome rearrangements are associated with eukaryotic evolutionary processes ranging from tumorigenesis to speciation. Rearrangements are especially common following interspecific hybridization, and some of these could be expected to have strong selective value. To test this expectation we created de novo interspecific yeast hybrids between two diverged but largely syntenic Saccharomyces species, S. cerevisiae and S. uvarum, then experimentally evolved them under continuous ammonium limitation. We discovered that a characteristic interspecific genome rearrangement arose multiple times in independently evolved populations. We uncovered nine different breakpoints, all occurring in a narrow ∼1-kb region of chromosome 14, and all producing an “interspecific fusion junction” within the MEP2 gene coding sequence, such that the 5′ portion derives from S. cerevisiae and the 3′ portion derives from S. uvarum. In most cases the rearrangements altered both chromosomes, resulting in what can be considered to be an introgression of a several-kb region of S. uvarum into an otherwise intact S. cerevisiae chromosome 14, while the homeologous S. uvarum chromosome 14 experienced an interspecific reciprocal translocation at the same breakpoint within MEP2, yielding a chimaeric chromosome; these events result in the presence in the cell of two MEP2 fusion genes having identical breakpoints. Given that MEP2 encodes for a high-affinity ammonium permease, that MEP2 fusion genes arise repeatedly under ammonium-limitation, and that three independent evolved isolates carrying MEP2 fusion genes are each more fit than their common ancestor, the novel MEP2 fusion genes are very likely adaptive under ammonium limitation. Our results suggest that, when homoploid hybrids form, the admixture of two genomes enables swift and otherwise unavailable evolutionary innovations. Furthermore, the architecture of the MEP2 rearrangement suggests a model for rapid introgression, a phenomenon seen in numerous eukaryotic phyla, that does not require repeated backcrossing to one of the parental species." @default.
• W2007881209 created "2016-06-24" @default.
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• W2007881209 date "2013-03-21" @default.
• W2007881209 modified "2023-10-01" @default.
• W2007881209 title "Recurrent Rearrangement during Adaptive Evolution in an Interspecific Yeast Hybrid Suggests a Model for Rapid Introgression" @default.
• W2007881209 cites W1254580001 @default.
• W2007881209 cites W1549400247 @default.
• W2007881209 cites W1639694146 @default.
• W2007881209 cites W1859373452 @default.
• W2007881209 cites W1963760518 @default.
• W2007881209 cites W1963846458 @default.
• W2007881209 cites W1965692132 @default.
• W2007881209 cites W1966885904 @default.
• W2007881209 cites W1967974152 @default.
• W2007881209 cites W1974096528 @default.
• W2007881209 cites W1975723196 @default.
• W2007881209 cites W1975749117 @default.
• W2007881209 cites W1978563881 @default.
• W2007881209 cites W1981977817 @default.
• W2007881209 cites W1988004702 @default.
• W2007881209 cites W1990144254 @default.
• W2007881209 cites W1991155924 @default.
• W2007881209 cites W1991427331 @default.
• W2007881209 cites W1995214055 @default.
• W2007881209 cites W1998362411 @default.
• W2007881209 cites W2003037782 @default.
• W2007881209 cites W2003867855 @default.
• W2007881209 cites W2007579185 @default.
• W2007881209 cites W2011071927 @default.
• W2007881209 cites W2011310198 @default.
• W2007881209 cites W2012719107 @default.
• W2007881209 cites W2012838063 @default.
• W2007881209 cites W2016297672 @default.
• W2007881209 cites W2023560061 @default.
• W2007881209 cites W2030631404 @default.
• W2007881209 cites W2034252391 @default.
• W2007881209 cites W2035745114 @default.
• W2007881209 cites W2043168428 @default.
• W2007881209 cites W2043504888 @default.
• W2007881209 cites W2047704970 @default.
• W2007881209 cites W2051293019 @default.
• W2007881209 cites W2052202220 @default.
• W2007881209 cites W2052558282 @default.
• W2007881209 cites W2053601335 @default.
• W2007881209 cites W2054624670 @default.
• W2007881209 cites W2055532978 @default.
• W2007881209 cites W2055758623 @default.
• W2007881209 cites W2056553003 @default.
• W2007881209 cites W2058529034 @default.
• W2007881209 cites W2061898017 @default.
• W2007881209 cites W2065932115 @default.
• W2007881209 cites W2067507447 @default.
• W2007881209 cites W2068160157 @default.
• W2007881209 cites W2068337028 @default.
• W2007881209 cites W2070085379 @default.
• W2007881209 cites W2082534286 @default.
• W2007881209 cites W2084314118 @default.
• W2007881209 cites W2085671121 @default.
• W2007881209 cites W2085896397 @default.
• W2007881209 cites W2092265987 @default.
• W2007881209 cites W2093785124 @default.
• W2007881209 cites W2097725098 @default.
• W2007881209 cites W2101442503 @default.
• W2007881209 cites W2101693398 @default.
• W2007881209 cites W2106433666 @default.
• W2007881209 cites W2107903364 @default.
• W2007881209 cites W2108234281 @default.
• W2007881209 cites W2109323227 @default.
• W2007881209 cites W2111427849 @default.
• W2007881209 cites W2117732943 @default.
• W2007881209 cites W2119180969 @default.
• W2007881209 cites W2120084974 @default.
• W2007881209 cites W2122362671 @default.
• W2007881209 cites W2123077816 @default.
• W2007881209 cites W2124560890 @default.
• W2007881209 cites W2124671442 @default.
• W2007881209 cites W2125153461 @default.
• W2007881209 cites W2126918260 @default.
• W2007881209 cites W2127229045 @default.
• W2007881209 cites W2127270784 @default.
• W2007881209 cites W2132926880 @default.
• W2007881209 cites W2136327879 @default.
• W2007881209 cites W2137148725 @default.
• W2007881209 cites W2137253682 @default.
• W2007881209 cites W2143497561 @default.
• W2007881209 cites W2145104577 @default.
• W2007881209 cites W2150095788 @default.
• W2007881209 cites W2151861350 @default.

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