FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007884854> ?p ?o ?g. }

• W2007884854 abstract "Activator protein-2 (AP-2) transcription factors are critically involved in a variety of fundamental cellular processes such as proliferation, differentiation and apoptosis and have also been implicated in carcinogenesis. Expression of the family members AP-2alpha and AP-2gamma is particularly well documented in malignancies of the female breast. Despite increasing evaluation of single AP-2 isoforms in mammary tumors the functional role of concerted expression of multiple AP-2 isoforms in breast cancer remains to be elucidated. AP-2 proteins can form homo- or heterodimers, and there is growing evidence that the net effect whether a cell will proliferate, undergo apoptosis or differentiate is partly dependent on the balance between different AP-2 isoforms.We simultaneously interfered with all AP-2 isoforms expressed in ErbB-2-positive murine N202.1A breast cancer cells by conditionally over-expressing a dominant-negative AP-2 mutant.We show that interference with AP-2 protein function lead to reduced cell number, induced apoptosis and increased chemo- and radiation-sensitivity. Analysis of global gene expression changes upon interference with AP-2 proteins identified 139 modulated genes (90 up-regulated, 49 down-regulated) compared with control cells. Gene Ontology (GO) investigations for these genes revealed Cell Death and Cell Adhesion and Migration as the main functional categories including 25 and 12 genes, respectively. By using information obtained from Ingenuity Pathway Analysis Systems we were able to present proven or potential connections between AP-2 regulated genes involved in cell death and response to chemo- and radiation therapy, (i.e. Ctgf, Nrp1, Tnfaip3, Gsta3) and AP-2 and other main apoptosis players and to create a unique network.Expression of AP-2 transcription factors in breast cancer cells supports proliferation and contributes to chemo- and radiation-resistance of tumor cells by impairing the ability to induce apoptosis. Therefore, interference with AP-2 function could increase the sensitivity of tumor cells towards therapeutic intervention." @default.
• W2007884854 created "2016-06-24" @default.
• W2007884854 creator A5007664976 @default.
• W2007884854 creator A5012376450 @default.
• W2007884854 creator A5015796348 @default.
• W2007884854 creator A5032327963 @default.
• W2007884854 creator A5033276205 @default.
• W2007884854 creator A5045439468 @default.
• W2007884854 creator A5067039880 @default.
• W2007884854 creator A5075855591 @default.
• W2007884854 creator A5078822596 @default.
• W2007884854 date "2010-05-11" @default.
• W2007884854 modified "2023-10-10" @default.
• W2007884854 title "Interference with Activator Protein-2 transcription factors leads to induction of apoptosis and an increase in chemo- and radiation-sensitivity in breast cancer cells" @default.
• W2007884854 cites W1860599747 @default.
• W2007884854 cites W1976121925 @default.
• W2007884854 cites W1979018234 @default.
• W2007884854 cites W1982300847 @default.
• W2007884854 cites W1997791083 @default.
• W2007884854 cites W2000034979 @default.
• W2007884854 cites W2004740605 @default.
• W2007884854 cites W2008661555 @default.
• W2007884854 cites W2017298826 @default.
• W2007884854 cites W2021469012 @default.
• W2007884854 cites W2023030470 @default.
• W2007884854 cites W2024200393 @default.
• W2007884854 cites W2024464498 @default.
• W2007884854 cites W2029506276 @default.
• W2007884854 cites W2032582014 @default.
• W2007884854 cites W2037768911 @default.
• W2007884854 cites W2039405498 @default.
• W2007884854 cites W2041510965 @default.
• W2007884854 cites W2041756868 @default.
• W2007884854 cites W2046570924 @default.
• W2007884854 cites W2046750894 @default.
• W2007884854 cites W2060213121 @default.
• W2007884854 cites W2061206375 @default.
• W2007884854 cites W2071750405 @default.
• W2007884854 cites W2076974754 @default.
• W2007884854 cites W2077852227 @default.
• W2007884854 cites W2115443599 @default.
• W2007884854 cites W2126115157 @default.
• W2007884854 cites W2130410032 @default.
• W2007884854 cites W2133070487 @default.
• W2007884854 cites W2135736569 @default.
• W2007884854 cites W2154794295 @default.
• W2007884854 cites W2161550927 @default.
• W2007884854 doi "https://doi.org/10.1186/1471-2407-10-192" @default.
• W2007884854 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2890516" @default.
• W2007884854 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20459791" @default.
• W2007884854 hasPublicationYear "2010" @default.
• W2007884854 type Work @default.
• W2007884854 sameAs 2007884854 @default.
• W2007884854 citedByCount "19" @default.
• W2007884854 countsByYear W20078848542012 @default.
• W2007884854 countsByYear W20078848542014 @default.
• W2007884854 countsByYear W20078848542016 @default.
• W2007884854 countsByYear W20078848542017 @default.
• W2007884854 countsByYear W20078848542018 @default.
• W2007884854 countsByYear W20078848542020 @default.
• W2007884854 countsByYear W20078848542021 @default.
• W2007884854 countsByYear W20078848542023 @default.
• W2007884854 crossrefType "journal-article" @default.
• W2007884854 hasAuthorship W2007884854A5007664976 @default.
• W2007884854 hasAuthorship W2007884854A5012376450 @default.
• W2007884854 hasAuthorship W2007884854A5015796348 @default.
• W2007884854 hasAuthorship W2007884854A5032327963 @default.
• W2007884854 hasAuthorship W2007884854A5033276205 @default.
• W2007884854 hasAuthorship W2007884854A5045439468 @default.
• W2007884854 hasAuthorship W2007884854A5067039880 @default.
• W2007884854 hasAuthorship W2007884854A5075855591 @default.
• W2007884854 hasAuthorship W2007884854A5078822596 @default.
• W2007884854 hasBestOaLocation W20078848541 @default.
• W2007884854 hasConcept C104317684 @default.
• W2007884854 hasConcept C121608353 @default.
• W2007884854 hasConcept C170493617 @default.
• W2007884854 hasConcept C190283241 @default.
• W2007884854 hasConcept C31573885 @default.
• W2007884854 hasConcept C502942594 @default.
• W2007884854 hasConcept C53345823 @default.
• W2007884854 hasConcept C54355233 @default.
• W2007884854 hasConcept C555283112 @default.
• W2007884854 hasConcept C62112901 @default.
• W2007884854 hasConcept C7876069 @default.
• W2007884854 hasConcept C86339819 @default.
• W2007884854 hasConcept C86803240 @default.
• W2007884854 hasConcept C95444343 @default.
• W2007884854 hasConcept C96232424 @default.
• W2007884854 hasConceptScore W2007884854C104317684 @default.
• W2007884854 hasConceptScore W2007884854C121608353 @default.
• W2007884854 hasConceptScore W2007884854C170493617 @default.
• W2007884854 hasConceptScore W2007884854C190283241 @default.
• W2007884854 hasConceptScore W2007884854C31573885 @default.
• W2007884854 hasConceptScore W2007884854C502942594 @default.
• W2007884854 hasConceptScore W2007884854C53345823 @default.
• W2007884854 hasConceptScore W2007884854C54355233 @default.
• W2007884854 hasConceptScore W2007884854C555283112 @default.
• W2007884854 hasConceptScore W2007884854C62112901 @default.
• W2007884854 hasConceptScore W2007884854C7876069 @default.
• W2007884854 hasConceptScore W2007884854C86339819 @default.

• next