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- W2007899478 abstract "Abstract N-Monodemethylation and N-oxidation were shown to be the major routes of metabolism of normethadone, (—)-methadone and (—)-isomethadone in vitro by hepatic microsomal preparations from rat, rabbit, guinea-pig, mouse and hamster. The rate of N-oxidation was decreased and the rate of N-demethylation was increased by the introduction of the methyl substituent into normethadone; the configuration of the methyl substituent influenced these processes. Km and Vmax values were determined for liver microsomal N-demethylation of normethadone, (—)-methadone and (—)-isomethadone by rat and guinea-pig and for the N-oxidation of normethadone by guinea-pig. The use of selective inhibitors showed that N-demethylation was not preceeded by N-oxidation in these compounds." @default.
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- W2007899478 date "1971-12-01" @default.
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- W2007899478 title "The influence of methyl substitution on the N-demethylation and N-oxidation of normethadone in animal species" @default.
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- W2007899478 doi "https://doi.org/10.1111/j.2042-7158.1971.tb09897.x" @default.
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