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- W2007903504 abstract "Simple excision, Mohs micrographic surgery (MMS), and electrodessication and curettage (ED&C) are standard surgical treatments for squamous cell carcinoma (SCC) of the skin, offering excellent local control with five year recurrence rates lower than 8.1%, 3.1%, and 3.7%, respectively. Organ transplant recipients (OTRs) have an increased incidence of SCC, and it is frequently unclear whether lesions are recurrences or are new primary lesions close to the original lesion. The objective of this study was to review the efficacy of excision and MMS for OTR patients with SCC in the context of a strict definition of regional tumor recurrence. Under this definition, any recurrence of the same histology within the same functional unit was considered a recurrence if it occurred within two years of the index SCC and not a recurrence, but a new cancer, if the same histology developed within the same functional unit but 2 years or later from successful treatment. A list of 100 consecutive patients was obtained from the Dermatologic Clinical and Outcomes Research database, from which 46 SCC OTR patients who had been treated definitively surgically. A chart review was performed. Each patient was classified by their type of transplant, duration and type of immunosuppressive regimen, first (index) SCC diagnosis, and the treatment of said diagnosis. Regional recurrence was defined as a SCC forming within the same cosmetic unit within two years. 6 out of 46, or 15.2% of the patients experienced recurrence with respect to their original index lesion. The time between the diagnosis of index lesion and the new regional lesion for each of the patients was 49, 51, 96, 364, 407, and 546 days. The mean number of lesions for these 46 patients was 4.35 (Range:1 - 33), with a median of 2 SCCs and a mode of 1 SCC. Using our definitions, the recurrence rate for this cohort of 15.2% appears to be greater than those seen in the general population. The concept of clinically silent concertized areas on the skin may prompt consideration of adjuvant regional therapies such as creams or radiation. Addressing the post-treatment regional formation of SCC may lead to a substantial reduction in the morbidity of OTR patients." @default.
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- W2007903504 date "2011-10-01" @default.
- W2007903504 modified "2023-09-26" @default.
- W2007903504 title "The Frequency of Regional Tumor Development in Organ Transplant Recipients Treated for Squamous Cell Carcinoma of the Skin" @default.
- W2007903504 doi "https://doi.org/10.1016/j.ijrobp.2011.06.1320" @default.
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