Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007905511> ?p ?o ?g. }
- W2007905511 endingPage "2045" @default.
- W2007905511 startingPage "2036" @default.
- W2007905511 abstract "Gene duplication provides genetic material required for functional diversification. An interesting example is the amyloid precursor protein (APP) protein family. The APP gene family has experienced both expansion and contraction during evolution. The three mammalian members have been studied quite extensively in combined knock out models. The underlying assumption is that APP, amyloid precursor like protein 1 and 2 (APLP1, APLP2) are functionally redundant. This assumption is primarily supported by the similarities in biochemical processing of APP and APLPs and on the fact that the different APP genes appear to genetically interact at the level of the phenotype in combined knockout mice. However, unique features in each member of the APP family possibly contribute to specification of their function. In the current review, we discuss the evolution and the biology of the APP protein family with special attention to the distinct properties of each homologue. We propose that the functions of APP, APLP1 and APLP2 have diverged after duplication to contribute distinctly to different neuronal events. Our analysis reveals that APLP2 is significantly diverged from APP and APLP1." @default.
- W2007905511 created "2016-06-24" @default.
- W2007905511 creator A5021772353 @default.
- W2007905511 creator A5090026679 @default.
- W2007905511 date "2013-05-23" @default.
- W2007905511 modified "2023-10-05" @default.
- W2007905511 title "Redundancy and divergence in the amyloid precursor protein family" @default.
- W2007905511 cites W1596272559 @default.
- W2007905511 cites W1596569815 @default.
- W2007905511 cites W1882078023 @default.
- W2007905511 cites W1932612562 @default.
- W2007905511 cites W1967656140 @default.
- W2007905511 cites W1969008973 @default.
- W2007905511 cites W1970756199 @default.
- W2007905511 cites W1977715568 @default.
- W2007905511 cites W1978272692 @default.
- W2007905511 cites W1981734441 @default.
- W2007905511 cites W1981941572 @default.
- W2007905511 cites W1982237245 @default.
- W2007905511 cites W1983924380 @default.
- W2007905511 cites W1984821426 @default.
- W2007905511 cites W1985901090 @default.
- W2007905511 cites W1987403479 @default.
- W2007905511 cites W1988986946 @default.
- W2007905511 cites W1995651729 @default.
- W2007905511 cites W1996518142 @default.
- W2007905511 cites W1996974474 @default.
- W2007905511 cites W1998454877 @default.
- W2007905511 cites W2000345419 @default.
- W2007905511 cites W2002158772 @default.
- W2007905511 cites W2003391115 @default.
- W2007905511 cites W2007093081 @default.
- W2007905511 cites W2009878500 @default.
- W2007905511 cites W2011117339 @default.
- W2007905511 cites W2015161609 @default.
- W2007905511 cites W2015714992 @default.
- W2007905511 cites W2015764953 @default.
- W2007905511 cites W2017957082 @default.
- W2007905511 cites W2018647432 @default.
- W2007905511 cites W2022171792 @default.
- W2007905511 cites W2025516399 @default.
- W2007905511 cites W2027003108 @default.
- W2007905511 cites W2027397361 @default.
- W2007905511 cites W2030249003 @default.
- W2007905511 cites W2030355018 @default.
- W2007905511 cites W2030680267 @default.
- W2007905511 cites W2038464976 @default.
- W2007905511 cites W2038977910 @default.
- W2007905511 cites W2040711118 @default.
- W2007905511 cites W2040757730 @default.
- W2007905511 cites W2041622179 @default.
- W2007905511 cites W2043726067 @default.
- W2007905511 cites W2044179716 @default.
- W2007905511 cites W2047219711 @default.
- W2007905511 cites W2048558199 @default.
- W2007905511 cites W2048621255 @default.
- W2007905511 cites W2049066073 @default.
- W2007905511 cites W2057712792 @default.
- W2007905511 cites W2058928585 @default.
- W2007905511 cites W2059114536 @default.
- W2007905511 cites W2060253596 @default.
- W2007905511 cites W2063147486 @default.
- W2007905511 cites W2066379345 @default.
- W2007905511 cites W2067425906 @default.
- W2007905511 cites W2067445072 @default.
- W2007905511 cites W2068042361 @default.
- W2007905511 cites W2070762013 @default.
- W2007905511 cites W2072514788 @default.
- W2007905511 cites W2076259821 @default.
- W2007905511 cites W2082617364 @default.
- W2007905511 cites W2084015178 @default.
- W2007905511 cites W2088730774 @default.
- W2007905511 cites W2091835577 @default.
- W2007905511 cites W2092414509 @default.
- W2007905511 cites W2097094825 @default.
- W2007905511 cites W2098979213 @default.
- W2007905511 cites W2102793650 @default.
- W2007905511 cites W2107356238 @default.
- W2007905511 cites W2107675335 @default.
- W2007905511 cites W2108263233 @default.
- W2007905511 cites W2108320273 @default.
- W2007905511 cites W2109193231 @default.
- W2007905511 cites W2110286211 @default.
- W2007905511 cites W2112878433 @default.
- W2007905511 cites W2113438288 @default.
- W2007905511 cites W2122561587 @default.
- W2007905511 cites W2123144246 @default.
- W2007905511 cites W2124757893 @default.
- W2007905511 cites W2125228440 @default.
- W2007905511 cites W2126527896 @default.
- W2007905511 cites W2126867710 @default.
- W2007905511 cites W2128884458 @default.
- W2007905511 cites W2129645512 @default.
- W2007905511 cites W2130081835 @default.
- W2007905511 cites W2130763296 @default.
- W2007905511 cites W2132991090 @default.
- W2007905511 cites W2135160221 @default.
- W2007905511 cites W2137137210 @default.