FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007907173> ?p ?o ?g. }

• W2007907173 endingPage "81" @default.
• W2007907173 startingPage "73" @default.
• W2007907173 abstract "This study was undertaken to show that rat purified islets can be used as a reliable tool to study some aspects of human islet's physiology related to CCKR occupation. Therefore, isolated foetal, adult human and rat islets were compared for (1) CCKR subtypes mRNA and protein expression and somatostatin (SS) mRNA and (2) co-localization of these receptors with insulin, glucagon and SS. Finally, rat islets were tested for their responsiveness to stimulation. Purified human and rat islets were used for CCKR subtypes and SS mRNA estimation by RT-PCR and protein by Western blots. Receptors and hormones co-localizations were evaluated by confocal microscopy. Hormones secretion served to determine rat islets responsiveness. Islets of both species express CCKA and CCKBR mRNA and proteins and SS mRNA. The CCKAR co-localizes with insulin and glucagon and the CCKBR with SS. Insulin release was increased 5-fold in response to 16 mM glucose and SS secretion reached 1.3- and 1.7-fold increments above basal in response to forskolin and IBMX. In conclusions, human and rat islets have comparable CCKR subtypes localized on the same cells; they also express SS mRNA. The rat islets are functional as they secrete but their response to hormonal stimulation remains to be clarified. These rat islets can thus serve as tools to study islets physiology." @default.
• W2007907173 created "2016-06-24" @default.
• W2007907173 creator A5044838440 @default.
• W2007907173 creator A5054254122 @default.
• W2007907173 creator A5087519994 @default.
• W2007907173 date "2004-09-01" @default.
• W2007907173 modified "2023-10-04" @default.
• W2007907173 title "The rat pancreatic islets: a reliable tool to study islet responses to cholecystokinin receptor occupation" @default.
• W2007907173 cites W11373782 @default.
• W2007907173 cites W1879914186 @default.
• W2007907173 cites W1964480823 @default.
• W2007907173 cites W1966563991 @default.
• W2007907173 cites W1972714301 @default.
• W2007907173 cites W1976732029 @default.
• W2007907173 cites W1979100850 @default.
• W2007907173 cites W1980090948 @default.
• W2007907173 cites W1988646125 @default.
• W2007907173 cites W1995273292 @default.
• W2007907173 cites W2003914166 @default.
• W2007907173 cites W2006215799 @default.
• W2007907173 cites W2009249974 @default.
• W2007907173 cites W2012171119 @default.
• W2007907173 cites W2012360351 @default.
• W2007907173 cites W2024476894 @default.
• W2007907173 cites W2029591217 @default.
• W2007907173 cites W2029737108 @default.
• W2007907173 cites W2029905671 @default.
• W2007907173 cites W2035430942 @default.
• W2007907173 cites W2056906860 @default.
• W2007907173 cites W2060333964 @default.
• W2007907173 cites W2062903307 @default.
• W2007907173 cites W2064234952 @default.
• W2007907173 cites W207069409 @default.
• W2007907173 cites W2075061146 @default.
• W2007907173 cites W2080827424 @default.
• W2007907173 cites W2080963091 @default.
• W2007907173 cites W2081004928 @default.
• W2007907173 cites W2081165789 @default.
• W2007907173 cites W2083541482 @default.
• W2007907173 cites W2083684701 @default.
• W2007907173 cites W2085826832 @default.
• W2007907173 cites W2112164509 @default.
• W2007907173 cites W2112754594 @default.
• W2007907173 cites W2124604698 @default.
• W2007907173 cites W2157865424 @default.
• W2007907173 cites W2171743401 @default.
• W2007907173 cites W4246795308 @default.
• W2007907173 cites W4294216491 @default.
• W2007907173 doi "https://doi.org/10.1016/j.regpep.2004.04.017" @default.
• W2007907173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15256276" @default.
• W2007907173 hasPublicationYear "2004" @default.
• W2007907173 type Work @default.
• W2007907173 sameAs 2007907173 @default.
• W2007907173 citedByCount "15" @default.
• W2007907173 countsByYear W20079071732013 @default.
• W2007907173 countsByYear W20079071732014 @default.
• W2007907173 countsByYear W20079071732015 @default.
• W2007907173 countsByYear W20079071732018 @default.
• W2007907173 countsByYear W20079071732020 @default.
• W2007907173 countsByYear W20079071732022 @default.
• W2007907173 crossrefType "journal-article" @default.
• W2007907173 hasAuthorship W2007907173A5044838440 @default.
• W2007907173 hasAuthorship W2007907173A5054254122 @default.
• W2007907173 hasAuthorship W2007907173A5087519994 @default.
• W2007907173 hasConcept C104317684 @default.
• W2007907173 hasConcept C105580179 @default.
• W2007907173 hasConcept C107539642 @default.
• W2007907173 hasConcept C126322002 @default.
• W2007907173 hasConcept C134018914 @default.
• W2007907173 hasConcept C165220095 @default.
• W2007907173 hasConcept C170493617 @default.
• W2007907173 hasConcept C24998067 @default.
• W2007907173 hasConcept C2776297358 @default.
• W2007907173 hasConcept C2777593968 @default.
• W2007907173 hasConcept C2778563252 @default.
• W2007907173 hasConcept C2779276759 @default.
• W2007907173 hasConcept C2779306644 @default.
• W2007907173 hasConcept C2779855799 @default.
• W2007907173 hasConcept C55493867 @default.
• W2007907173 hasConcept C71924100 @default.
• W2007907173 hasConcept C86803240 @default.
• W2007907173 hasConceptScore W2007907173C104317684 @default.
• W2007907173 hasConceptScore W2007907173C105580179 @default.
• W2007907173 hasConceptScore W2007907173C107539642 @default.
• W2007907173 hasConceptScore W2007907173C126322002 @default.
• W2007907173 hasConceptScore W2007907173C134018914 @default.
• W2007907173 hasConceptScore W2007907173C165220095 @default.
• W2007907173 hasConceptScore W2007907173C170493617 @default.
• W2007907173 hasConceptScore W2007907173C24998067 @default.
• W2007907173 hasConceptScore W2007907173C2776297358 @default.
• W2007907173 hasConceptScore W2007907173C2777593968 @default.
• W2007907173 hasConceptScore W2007907173C2778563252 @default.
• W2007907173 hasConceptScore W2007907173C2779276759 @default.
• W2007907173 hasConceptScore W2007907173C2779306644 @default.
• W2007907173 hasConceptScore W2007907173C2779855799 @default.
• W2007907173 hasConceptScore W2007907173C55493867 @default.
• W2007907173 hasConceptScore W2007907173C71924100 @default.
• W2007907173 hasConceptScore W2007907173C86803240 @default.

• next