FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007923993> ?p ?o ?g. }

• W2007923993 endingPage "3745" @default.
• W2007923993 startingPage "3735" @default.
• W2007923993 abstract "Orally delivered, inactivated whole-cell vaccines are safe methods of inducing local and systemic immunity. To increase surface proteins associated with adherence and invasion, Shigella sonnei were grown in BHI broth containing deoxycholate. A whole-cell vaccine (SsWC) was then produced by formalin inactivation. In pre-clinical studies, the SsWC vaccine was immunogenic and protected against S. sonnei-induced keratoconjunctivitis in the guinea pig model. In a randomized, double-blind, placebo-controlled, Phase I study, 10 evaluable subjects received either three doses of SsWC on Days 0, 14, and 28 (N = 3); five doses of SsWC on Days 0, 2, 4, 6, and 28 (N = 4); or placebo (N = 3). Each dose contained 2.0 x 10(10) inactivated cells. Serum and fecal antibodies against SsWC, LPS, and IpaC were measured by ELISA. A > or = 4-fold increase in titer was considered significant. Both SsWC dosing regimens were well tolerated. No fever or severe gastrointestinal symptoms were noted by any of the vaccinated subjects. Antibody responses were similar in the two dosing groups. Serum IgG or IgA responses to SsWC were seen in six of seven vaccinees (86%), to LPS in four of seven (57%), and to IpaC in five of seven (61%). Fecal IgA responses to these three antigens developed in five of five, three of five, and three of five subjects, respectively. Among the seven vaccinees, geometric mean rises in serum IgA levels to all three immunogens were significant; IgG increases trended toward significance (paired one-tailed t-test). We conclude that SsWC was immunogenic and protective in animal studies and well tolerated and immunogenic in a Phase I trial." @default.
• W2007923993 created "2016-06-24" @default.
• W2007923993 creator A5004177094 @default.
• W2007923993 creator A5007253609 @default.
• W2007923993 creator A5011786695 @default.
• W2007923993 creator A5015827554 @default.
• W2007923993 creator A5017229625 @default.
• W2007923993 creator A5034107492 @default.
• W2007923993 creator A5051174207 @default.
• W2007923993 creator A5065436034 @default.
• W2007923993 creator A5067017456 @default.
• W2007923993 creator A5068844395 @default.
• W2007923993 creator A5076831521 @default.
• W2007923993 creator A5084989573 @default.
• W2007923993 date "2006-05-01" @default.
• W2007923993 modified "2023-10-16" @default.
• W2007923993 title "Safety and immunogenicity of an oral, inactivated, whole-cell vaccine for Shigella sonnei: preclinical studies and a Phase I trial" @default.
• W2007923993 cites W1501327568 @default.
• W2007923993 cites W1607190564 @default.
• W2007923993 cites W1765581605 @default.
• W2007923993 cites W1788648740 @default.
• W2007923993 cites W1896912566 @default.
• W2007923993 cites W1926928623 @default.
• W2007923993 cites W2011160104 @default.
• W2007923993 cites W2040313647 @default.
• W2007923993 cites W2049486788 @default.
• W2007923993 cites W2058633224 @default.
• W2007923993 cites W2072629427 @default.
• W2007923993 cites W2080980546 @default.
• W2007923993 cites W2086874136 @default.
• W2007923993 cites W2096143278 @default.
• W2007923993 cites W2110642681 @default.
• W2007923993 cites W2127572566 @default.
• W2007923993 cites W2129397980 @default.
• W2007923993 cites W2129891858 @default.
• W2007923993 cites W2132247441 @default.
• W2007923993 cites W2156408870 @default.
• W2007923993 cites W2157454375 @default.
• W2007923993 cites W2157739202 @default.
• W2007923993 cites W2164381068 @default.
• W2007923993 cites W2169551048 @default.
• W2007923993 cites W2324551704 @default.
• W2007923993 cites W2334903131 @default.
• W2007923993 cites W2345832444 @default.
• W2007923993 cites W2402468535 @default.
• W2007923993 doi "https://doi.org/10.1016/j.vaccine.2005.07.014" @default.
• W2007923993 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16095766" @default.
• W2007923993 hasPublicationYear "2006" @default.
• W2007923993 type Work @default.
• W2007923993 sameAs 2007923993 @default.
• W2007923993 citedByCount "57" @default.
• W2007923993 countsByYear W20079239932012 @default.
• W2007923993 countsByYear W20079239932013 @default.
• W2007923993 countsByYear W20079239932014 @default.
• W2007923993 countsByYear W20079239932015 @default.
• W2007923993 countsByYear W20079239932016 @default.
• W2007923993 countsByYear W20079239932017 @default.
• W2007923993 countsByYear W20079239932018 @default.
• W2007923993 countsByYear W20079239932019 @default.
• W2007923993 countsByYear W20079239932020 @default.
• W2007923993 countsByYear W20079239932021 @default.
• W2007923993 countsByYear W20079239932022 @default.
• W2007923993 countsByYear W20079239932023 @default.
• W2007923993 crossrefType "journal-article" @default.
• W2007923993 hasAuthorship W2007923993A5004177094 @default.
• W2007923993 hasAuthorship W2007923993A5007253609 @default.
• W2007923993 hasAuthorship W2007923993A5011786695 @default.
• W2007923993 hasAuthorship W2007923993A5015827554 @default.
• W2007923993 hasAuthorship W2007923993A5017229625 @default.
• W2007923993 hasAuthorship W2007923993A5034107492 @default.
• W2007923993 hasAuthorship W2007923993A5051174207 @default.
• W2007923993 hasAuthorship W2007923993A5065436034 @default.
• W2007923993 hasAuthorship W2007923993A5067017456 @default.
• W2007923993 hasAuthorship W2007923993A5068844395 @default.
• W2007923993 hasAuthorship W2007923993A5076831521 @default.
• W2007923993 hasAuthorship W2007923993A5084989573 @default.
• W2007923993 hasConcept C126322002 @default.
• W2007923993 hasConcept C142724271 @default.
• W2007923993 hasConcept C147483822 @default.
• W2007923993 hasConcept C159654299 @default.
• W2007923993 hasConcept C203014093 @default.
• W2007923993 hasConcept C204787440 @default.
• W2007923993 hasConcept C27081682 @default.
• W2007923993 hasConcept C2776986154 @default.
• W2007923993 hasConcept C2777288759 @default.
• W2007923993 hasConcept C2780868878 @default.
• W2007923993 hasConcept C2781065037 @default.
• W2007923993 hasConcept C2911111840 @default.
• W2007923993 hasConcept C32611913 @default.
• W2007923993 hasConcept C523546767 @default.
• W2007923993 hasConcept C54355233 @default.
• W2007923993 hasConcept C61716771 @default.
• W2007923993 hasConcept C71924100 @default.
• W2007923993 hasConcept C86803240 @default.
• W2007923993 hasConcept C89423630 @default.
• W2007923993 hasConceptScore W2007923993C126322002 @default.
• W2007923993 hasConceptScore W2007923993C142724271 @default.
• W2007923993 hasConceptScore W2007923993C147483822 @default.

• next