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- W2007934067 abstract "Purpose of review This review examines new literature published in 2006 and 2007 on steroid-sensitive nephrotic syndrome. Recent findings Steroid-sensitive nephrotic syndrome has long been thought to be due to lymphocyte-derived circulating factors leading to podocyte injury with subsequent proteinuria. New studies support this mechanism and implicate the T helper 2 cytokine IL-13. In addition a genetic mutation in familial nephrotic syndrome has been reported in a child, who responded to corticosteroid therapy. There are new clinical trial data supporting the efficacy of levamisole in steroid-sensitive nephrotic syndrome and preliminary trial data on mycophenolate mofetil supporting its efficacy as a steroid-sparing agent. Case reports support the use of the B cell-depleting antibody rituximab in steroid-sensitive nephrotic syndrome. Finally there is a meta-analysis of six studies suggesting an increase in the incidence of focal and segmental glomerulosclerosis in steroid-sensitive nephrotic syndrome over the last 20 years. Summary Progress has been made towards elucidating the cause of steroid-sensitive nephrotic syndrome. Data from adequately powered randomized controlled trials are still required to evaluate therapies for frequently relapsing and steroid-dependent steroid-sensitive nephrotic syndrome." @default.
- W2007934067 created "2016-06-24" @default.
- W2007934067 creator A5051609819 @default.
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- W2007934067 date "2008-04-01" @default.
- W2007934067 modified "2023-09-24" @default.
- W2007934067 title "Evaluation and management of steroid-sensitive nephrotic syndrome" @default.
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- W2007934067 doi "https://doi.org/10.1097/mop.0b013e3282f4307a" @default.
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