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- W2007938504 abstract "To evaluate population-based cardiovascular risk scores and coronary artery calcification scores (CACS) in amputees.A retrospective cohort study of 1300 veterans in a cardiac computed tomography database.1B Veterans Administration medical center.A total of 76 amputees and similar number of age-, gender-, and Framingham Risk Scores (FRS)-matched control subjects.The amputee population was identified and compared for CACS and traditional cardiac risk factors. Two control groups were used: control group 1, with known risk factors including diabetes mellitus, and control group 2, with all risk factors without diabetes mellitus.Statistical associations between amputee and control group FRS scores, CACS, and other cardiac risk factors were assessed.The study included 57 nontraumatic and 19 traumatic amputees with an average age of 62.4 years. Sixty-six amputees were in the low-to-intermediate cardiac risk groups according to FRS. Despite this classification, the mean CACS were significantly higher in amputees (1285 ± 18) than in either of the control groups: control group 1 (540 ± 84) and control group 2 (481 ± 11), P < .001. CACS also were significantly higher in the nontraumatic subject group (1595 ± 12) compared with the traumatic group (356 ± 57; P < .001). Upon categorization of CACS based on probability of coronary artery disease (CAD), 76% of amputees had a CACS >100 and 38% of amputees had a CACS >1000. Interestingly, CACS were almost the same in finger/toe amputations compared with an above-knee amputation, indicating an already ongoing CAD process irrespective of level of amputation. The predominant clinical significant cardiac risk factors in amputees are hypertension (89.5%), P < .005; chronic kidney disease (31.6%), P < .001; dyslipidemia (72.4%), P < .04; and insulin resistance. Total cholesterol, low-density lipoprotein, and high-density lipoprotein levels were nonsignificantly low in all amputees. Triglycerides were particularly higher in traumatic patients compared with nontraumatic patients, with the triglycerides/high-density lipoprotein ratio >7.This study demonstrates that amputees have a much greater burden of underlying atherosclerotic disease as detected by CACS than do control subjects matched by Framingham risk stratification. Early screening for CAD and aggressive targeted interventions may be an important part of management to reduce early mortality after amputation." @default.
- W2007938504 created "2016-06-24" @default.
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- W2007938504 date "2012-06-12" @default.
- W2007938504 modified "2023-09-25" @default.
- W2007938504 title "Amputation and Cardiac Comorbidity: Analysis of Severity of Cardiac Risk" @default.
- W2007938504 cites W118162583 @default.
- W2007938504 cites W1435108658 @default.
- W2007938504 cites W1453335796 @default.
- W2007938504 cites W1490692400 @default.
- W2007938504 cites W171403732 @default.
- W2007938504 cites W18169544 @default.
- W2007938504 cites W190922227 @default.
- W2007938504 cites W1964465210 @default.
- W2007938504 cites W1969678022 @default.
- W2007938504 cites W1973979958 @default.
- W2007938504 cites W1974946573 @default.
- W2007938504 cites W1979003718 @default.
- W2007938504 cites W1982149887 @default.
- W2007938504 cites W1984832218 @default.
- W2007938504 cites W1986724923 @default.
- W2007938504 cites W1992109641 @default.
- W2007938504 cites W1992835868 @default.
- W2007938504 cites W1994568523 @default.
- W2007938504 cites W1999248316 @default.
- W2007938504 cites W2002514645 @default.
- W2007938504 cites W2003438968 @default.
- W2007938504 cites W2004729448 @default.
- W2007938504 cites W2005793810 @default.
- W2007938504 cites W2006093860 @default.
- W2007938504 cites W2009518130 @default.
- W2007938504 cites W2012905414 @default.
- W2007938504 cites W2018637734 @default.
- W2007938504 cites W2024017971 @default.
- W2007938504 cites W2025136911 @default.
- W2007938504 cites W2025698096 @default.
- W2007938504 cites W2026985226 @default.
- W2007938504 cites W2032485049 @default.
- W2007938504 cites W2034148976 @default.
- W2007938504 cites W2039908299 @default.
- W2007938504 cites W2041239381 @default.
- W2007938504 cites W2041540623 @default.
- W2007938504 cites W2047131110 @default.
- W2007938504 cites W2051947299 @default.
- W2007938504 cites W2054373210 @default.
- W2007938504 cites W2056524540 @default.
- W2007938504 cites W2060401590 @default.
- W2007938504 cites W2063463709 @default.
- W2007938504 cites W2070351043 @default.
- W2007938504 cites W2070559479 @default.
- W2007938504 cites W2072269053 @default.
- W2007938504 cites W2075474338 @default.
- W2007938504 cites W2078996133 @default.
- W2007938504 cites W2081570709 @default.
- W2007938504 cites W2083368452 @default.
- W2007938504 cites W2085378756 @default.
- W2007938504 cites W2092729881 @default.
- W2007938504 cites W2096978392 @default.
- W2007938504 cites W2097902237 @default.
- W2007938504 cites W2107477253 @default.
- W2007938504 cites W2108559881 @default.
- W2007938504 cites W2117913791 @default.
- W2007938504 cites W2122691873 @default.
- W2007938504 cites W2123477658 @default.
- W2007938504 cites W2128321090 @default.
- W2007938504 cites W2129837832 @default.
- W2007938504 cites W2129984493 @default.
- W2007938504 cites W2130203318 @default.
- W2007938504 cites W2130748218 @default.
- W2007938504 cites W2133211347 @default.
- W2007938504 cites W2133981480 @default.
- W2007938504 cites W2135373624 @default.
- W2007938504 cites W2137064522 @default.
- W2007938504 cites W2144112846 @default.
- W2007938504 cites W2148308491 @default.
- W2007938504 cites W2154023207 @default.
- W2007938504 cites W2154553161 @default.
- W2007938504 cites W2155885863 @default.
- W2007938504 cites W2156112841 @default.
- W2007938504 cites W2157894862 @default.
- W2007938504 cites W2160222342 @default.
- W2007938504 cites W2170342663 @default.
- W2007938504 cites W2317163768 @default.
- W2007938504 cites W2320395245 @default.
- W2007938504 cites W2321390987 @default.
- W2007938504 cites W2328615536 @default.
- W2007938504 cites W2333251385 @default.
- W2007938504 cites W3140194949 @default.
- W2007938504 cites W4231887873 @default.
- W2007938504 cites W4237483467 @default.
- W2007938504 cites W4297578547 @default.
- W2007938504 doi "https://doi.org/10.1016/j.pmrj.2012.04.017" @default.
- W2007938504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22698850" @default.