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• W2007939498 abstract "Objectives The primary aim of this study was to examine the associations between endogenous hormone levels and symptoms other than hot flashes in a sample of midlife women. Methods Data from a community-based sample of 603 women aged 45–54 years who had never used hormone therapy were analyzed. Each participant completed a questionnaire to obtain data on demographic and lifestyle characteristics as well as symptoms, including headache, insomnia, vision problems, vaginal discharge and dryness, irritability, and incontinence. In addition, each participant provided a blood sample that was used to measure estrogen, androgen, and sex hormone binding globulin (SHBG) concentrations by enzyme-linked immunosorbent assay. Results Prevalence rates of symptoms ranged from 51.4% (irritability) to 18.6% (vision problems). In adjusted analyses, the free estradiol index (FEI) was significantly and positively associated with the reporting of insomnia (odds ratio (OR) 1.28; 95% confidence interval (CI) 1.01–1.61). Further, higher SHBG levels were significantly associated with lower odds of reporting vision problems (OR 0.44; 95% CI 0.23–0.81). Conclusions This study provides evidence that hormones are associated with insomnia and visual problems during midlife. However, some of these results conflict with previous findings. Given the overall paucity of literature on these issues, more investigation is warranted." @default.
• W2007939498 created "2016-06-24" @default.
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• W2007939498 date "2008-02-01" @default.
• W2007939498 modified "2023-10-14" @default.
• W2007939498 title "Endogenous hormones, participant characteristics, and symptoms among midlife women" @default.
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• W2007939498 doi "https://doi.org/10.1016/j.maturitas.2008.01.003" @default.
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