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• W2007941927 abstract "<h2>Abstract</h2> Renal vascular resistance in deoxycorticosterone acetate (DOCA) salt–treated uninephrectomized rats is increased by high dietary chloride. Because DOCA salt–hypertensive rats exhibit an increased urinary excretion of thromboxane B₂ (TXB₂), a metabolite of thromboxane A₂ (TXA₂), the increased TXB₂ excretion by DOCA salt–treated rats could relate to elevated dietary chloride, increased blood pressure, and/or the presence of intact renal tubules. We hypothesized that high NaCl intake, resulting in an elevated tubular chloride excretion, stimulates TXA₂ production. A result of that production could be renal vasoconstriction. Baseline blood pressures were measured for 10 days, and then the rats were treated with DOCA (30 mg/kg) and fed (1) normal NaCl, (2) normal sodium with high chloride, or (3) high sodium chloride (NaCl) for 4.5 weeks. Next, the rats were uninephrectomized (1K) or unihydronephrectomized (1KHK) to yield one kidney without an intact tubular system and therefore no macula densa. Two and a half weeks later, urinary excretion of TXB₂ was determined. DOCA-high NaCl-fed 1KHK or 1K rats had significant increases in systemic blood pressure to 172 ± 12 and 190 ± 5 mm Hg, respectively, compared with no significant increase in blood pressure among the other groups. Urinary TXB₂ excretion was increased to 29 ± 4 pg per 24 hours per gram of body weight in all DOCA-treated 1KHK and 1K animals regardless of diet compared with DOCA-treated animals with two intact kidneys (13 ± 2 pg per 24 hours per gram of body weight). DOCA treatment in rats with one functional kidney results in the excretion of high levels of urinary TXB₂ unrelated to dietary chloride load, blood pressure, or intact renal tubules. (J Lab Clin Med 2000;135:493-7)" @default.
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• W2007941927 date "2000-06-01" @default.
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• W2007941927 title "Dietary chloride does not correlate with urinary thromboxane in deoxycorticosterone acetate–treated rats" @default.
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• W2007941927 doi "https://doi.org/10.1067/mlc.2000.106808" @default.
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