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- W2007942329 abstract "A screening hemostasis analysis in a 75 year-old female with metastatic adenocarcinoma of the colon, revealed a normal prothrombin time and a prolonged partial thromboplastin time which was not corrected by mixing the patient's plasma with normal plasma. Specific assays of blood coagulation factors revealed a normal level of factors VIII and IX, a factor XI level of 2.5 percent and a factor XII level of 10 percent. Addition of the patient's plasma to normal plasma resulted in inhibition of the factor XI and factor XII activity. On gel filtration of the patient's plasma the inhibitor was eluted in a single peak coinciding with IgM. Addition of 7S-immunoglobulins isolated from goat antisera against human IgM (μ chain) completely inactivated the inhibitor. Antibodies against IgG (γ chain) had a slight neutralizing effect whereas anti-IgA antibodies (anti-α-chain) failed to affect the inhibitor. Treatment of the patient's plasma with 2-mercaptoethanol destroyed the inhibitor. It is concluded that the patient's plasma contained IgM antibody or antibodies directed against factor XI and possibly against factor XII." @default.
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- W2007942329 title "A case of IgM antibodies which inhibit the contact activation of blood coagulation" @default.
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- W2007942329 doi "https://doi.org/10.1016/0049-3848(78)90282-7" @default.
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