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- W2007942622 abstract "Disruption of the IL-4 gene in two inbred mouse strains revealed a dual role of IL-4 in Staphylococcus aureus sepsis and arthritis depending on the host's genetic background. IL-4 was protective in 129SV mice, since 5 days after S. aureus inoculation IL-4(-/-) mice displayed 70% mortality as compared to survival of all 129SV wild-type counterparts. On the other hand, IL-4 was detrimental in C57BL/6 mice, since survival of IL-4(-/-) C57BL/6 mice was increased, as compared to wild-type controls, due to decreased staphylococcal growth. Altogether, our results show the dual role of IL-4 in S. aureus sepsis and arthritis, depending on the genetic background of the host." @default.
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- W2007942622 date "1999-08-01" @default.
- W2007942622 modified "2023-09-27" @default.
- W2007942622 title "Outcome ofStaphylococcus aureus -triggered sepsis and arthritis in IL-4-deficient mice depends on the genetic background of the host" @default.
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- W2007942622 doi "https://doi.org/10.1002/(sici)1521-4141(199908)29:08<2400::aid-immu2400>3.0.co;2-e" @default.
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