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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2007942912> ?p ?o ?g. }

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• W2007942912 abstract "In an effort to discover potent inhibitors of the antiapoptotic protein Bcl-xL, a systematic in vitro evaluation was undertaken on extracts prepared from various parts of Vietnamese plants. The ethyl acetate extracts obtained from the leaves and flowers of Combretum sundaicum and the leaves of Lantana camara were selected for their interaction with the Bcl-xL/Bak association. Bioassay-guided purification of these species led to the isolation of 15 pentacyclic triterpenoids (1−15) possessing olean-12-en-28-oic acid and olean-12-en-29-oic acid aglycons, of which compounds 1−6 and 8−10 are new. Five compounds exhibited binding activity with Ki values between 5.3 and 17.8 μM. The cytotoxic activity of 1−15 was also evaluated on various cancer cell lines." @default.
• W2007942912 created "2016-06-24" @default.
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• W2007942912 date "2009-07-02" @default.
• W2007942912 modified "2023-09-26" @default.
• W2007942912 title "Cytotoxic Pentacyclic Triterpenoids from <i>Combretum sundaicum</i> and <i>Lantana camara</i> as Inhibitors of Bcl-xL/BakBH3 Domain Peptide Interaction" @default.
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• W2007942912 doi "https://doi.org/10.1021/np900192r" @default.
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